Multicenter Registry on Microvascular Dysfunction - Searching a New Ach Spasm Definition

NCT06125392 · tracked via the Priya Life Science Germany tracker

Sponsor

Johannes Gutenberg University Mainz

Phase

Observational

Started

2023-09-30

Last updated

2024-11-01

Condition(s) studied

Coronary Microvascular DiseaseCoronary Vasospasm

Investigational drug(s) / intervention(s)

Coronary physiology assessment

Coronary physiology assessment: Resting distal coronary to aortic pressure ratio, resting flow ratio, fractional flow reserve, Coronary Flow Reserve and Microvascular resistance using the thermodilution method and papaverin or adenosine, Resting distal coronary to aortic pressure ratio, resting flow ratio, fractional flow reserve, Coronary Flow Reserve and Microvascular resistance using the thermodilution method and acetylcholine.

Study summary

The MICRO-SNAPE registry will collect data from patients undergoing investigation of microvascular dysfunction and coronary spasm in Europe and North America.

Eligibility

Sex

ALL

Min age

18 Years

Max age

90 Years

Healthy volunteers

Inclusion Criteria: * Patients who underwent combined measurements of coronary pressure and flow in at least 1 native coronary artery in response to endothelium dependent and independent vasodilators. Exclusion Criteria: * Hemodynamic instability * Age \<18 years

Primary outcome measure(s)

Identification of endotypes of coronary vasomotor function — immediately after the invasive measurement
Patients will be classified in different endotypes according to the pattern of their responses to endothelium-dependent and independent vasodilators.

Trial sites (1)

Facility	City	Region	Status
Center of Cardiology, Cardiology I, university hospital Mainz	Mainz	Rhineland-Palatinate	Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06125392 on ClinicalTrials.gov ↗ ← All trials in Germany