The purpose of this study is to assess respiratory variation of carotid doppler peak velocity (∆CDPV) for prediction of fluid responsiveness during major abdominal surgery.
Eligibility
Sex
ALL
Min age
18 Years
Max age
80 Years
Healthy volunteers
No
Inclusion Criteria:
* Age 18-80 years
* written informed consent
* scheduled major abdominal surgery
Exclusion Criteria:
* Age \<18 or \>80 years
* pregnancy
* SIRS or sepsis
* any kind of cardiac arrhythmia
* known valve disease
* known heart failure
* any kind of known carotid stenosis
* carotid doppler peak velocity \>182 cm/s before baseline measurement (expected stenosis)
* missing indication for invasive arterial blood pressure monitoring (IBP) not related to the study
* peripheral artery disease (PAD)
* BMI \> 35 kg/m2
* intraabdominal hypertension
* ASA-PSC of 4
* severe lung disease (e.g. COPD grade 3, fibrosis)
* esophageal disease of any kind
* participation in another clinical study
Primary outcome measure(s)
Change in stroke volume following a fluid bolus. — Immediately before and 1 minute after completion of each fluid bolus. A rise in stroke volume of ≥10% following a fluid bolus of 7ml/kg Ideal Body Weight is considered to reflect fluid responsiveness. Measurements will be assessed through esophageal doppler monitoring.
Trial sites (1)
Facility
City
Region
Status
Department of Anesthesiology, Johannes-Gutenberg University Medical Center
Mainz
Rhineland-Palatinate
Recruiting
More Johannes Gutenberg University Mainz trials in Germany
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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