single bout of moderate intensity continuous training (MICT)single bout of High Intensity Interval Training (HIIT)waiting control
single bout of moderate intensity continuous training (MICT): the MICT consists of 60 min continuous cycling
single bout of High Intensity Interval Training (HIIT): HIIT consists of 10-min warm-up at the power output corresponding to 50% peak power output (PPO), 4 x 4-min intervals at a power output corresponding to 75% PPO with a 4-min active resting period at 30% PPO to recover
waiting control: sitting in a waiting room for 60 min
Study summary
The overarching goal of the current study is to investigate the effect of one acute bout of exercise on the brain insulin responsiveness in a cross-over study design. To this end, investigators will compare the effect of two single endurance exercise sessions with different intensities, namely moderate intensity continuous training (MICT) and high-intensity-interval-training (HIIT), which will be performed in a randomized order. This will be compared to a waiting control condition.
Eligibility
Sex
ALL
Min age
20 Years
Max age
65 Years
Healthy volunteers
Accepted
Inclusion Criteria:
* BMI between ≥ 19.5 to 39 kg/m2-
* Less than 150 min/week for moderate-intensity physical activity
* Less than 75 min/week for Vigorous- intensity exercise (WHO recommendations for regular physical activity of adults)
* Written consent to participate in the study
* Written consent to be informed about incidental findings
Exclusion Criteria
* Type 2 diabetes, cardiovascular diseases such as chronic heart failure, myocardial infarction, status post stroke
* Limitations to participate in ergometer-based exercise (balance and coordination disorders, orthopedic problems, …)
* Insufficient knowledge of the German language
* Persons who cannot legally give consent
* Pregnancy or lactation
* History of severe mental or somatic disorders including neurological diseases (incl. epileptic seizures and migraines)
* Taking psychotropic drugs
* Taking medications that influence glucose metabolism
* Regular use of analgesic drugs
* Taking anticoagulant agents
* Previous bariatric surgery
* Acute infection within the last 4 weeks
* Hemoglobin values less than 12g/dl for women, less than 14 g/dl for men
* Other diseases that in the opinion of the investigator may jeopardize the success of the study or indicate a risk to the volunteer
* Current participation in a lifestyle intervention study or a pharmaceutical study
* Metal implants which cannot be removed as pacemakers, artificial heart valve, electrical devices as insulin pumps, large tattoos, retainer over more than 4 teeth, contraceptive coil, implanted magnetic metal parts as screws or plates after a surgery
* Persons with claustrophobia
* Temperature-sensitive person
* Persons with tinnitus or increased sensitivity to loud sounds
Primary outcome measure(s)
Cerebral response after intranasal insulin administration — 1 hour after exercise or waiting control The resting-state cerebral response from before to after intranasal insulin administration after a single bout of HIIT or MICT exercise compared to a control condition without exercise (i.e., waiting control)
Trial sites (1)
Facility
City
Region
Status
University Clinic Tübingen, Department of Internal Medicine IV
Tübingen
Germany
Recruiting
More University Hospital Tuebingen trials in Germany
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
We use cookies to analyse site traffic and improve your experience. With your consent, we may also use cookies for advertising. You can change your choice at any time.