on-pump surgery: the surgery will be performed "on-pump"
off-pump surgery: the surgery will be performed "off-pump"
Study summary
This study investigates the question of whether there are differences in the plasma concentration of hormones of the RAAS-axis between patients undergoing on-pump cardiac surgery and those receiving off-pump surgery
Eligibility
Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria:
1. adult patients undergoing on- or off-pump coronary artery bypass graft surgery
2. written informed consent
Exclusion Criteria:
1. emergency surgery in the context of acute coronary syndrome
2. ACE-inhibitor or Angiotensin 1 (AT1)-receptor-blocker intake that was not paused on the day of surgery
3. Chronic kidney disease with estimated glomerular filtration rate (eGFR)\<30ml/min/1.73m²
4. Severe structural lung disease (asbestosis, silicosis, severe sarcoidosis, tuberculosis, severe emphysema, chronic obstructive pulmonary disease (COPD) Gold 3-4, lung fibrosis)
5. Chronic pulmonary hypertension
6. Pregnancy or breastfeeding
7. Persons with any kind of dependency on the investigator or employed by the institution responsible or investigator
8. Persons held in an institution by legal or official order
Primary outcome measure(s)
Differences in plasma concentration of Angiotensinogen — between induction of anesthesia and immediately after surgical intervention
Differences in plasma concentration of Renin — between induction of anesthesia and immediately after surgical intervention
Differences in plasma concentration of Angiotensin I — between induction of anesthesia and immediately after surgical intervention
Differences in plasma concentration of Angiotensin converting enzyme (ACE) — between induction of anesthesia and immediately after surgical intervention
Differences in plasma concentration of Angiotensin II — between induction of anesthesia and immediately after surgical intervention
Differences in plasma concentration of Aldosterone — between induction of anesthesia and immediately after surgical intervention
Trial sites (2)
Facility
City
Region
Status
Deutsches Herzzentrum der Charité
Berlin
Germany
Recruiting
University Hospital Münster; Department of Anesthesiology, Intensive Care Medicine and Pain Medicine
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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