Standard Dose Continuous Renal Replacement Therapy (CRRT) Versus Low-Dose CRRT ( KETZEREI )

NCT06021288 · tracked via the Priya Life Science Germany tracker

Sponsor

Universität Münster

Phase

Not applicable

Started

2023-10-02

Last updated

2024-11-27

Condition(s) studied

Critical IllnessAcute Kidney Injury

Investigational drug(s) / intervention(s)

Effluent dose of CRRT

Effluent dose of CRRT: The effluent dose of the CRRT will be performed according to study group for 7 days or up to the end of CRRT, whatever occurs first.

Study summary

Acute kidney injury (AKI) is a well-recognized complication in critically ill patients, which often leads to the necessity of mechanical kidney support (CRRT).

In current therapeutic regimes, CRRT is used to strictly prevent azotaemia. Thus recent clinical observations, as well as data from animal testing suggest a link between controlled azotaemia and faster renal recovery in AKI patients.

The aim of the study is to improve renal recovery.

Eligibility

Sex

ALL

Min age

18 Years

Max age

—

Healthy volunteers

Inclusion Criteria: * Adult patients (age ≥18 years) * Critically ill patients with AKI + in need of CRRT * Written informed consent Exclusion Criteria: * Chronic dialysis dependency * Chronic kidney disease with estimated glomerular filtration rate (eGFR) \<30 ml/min/1.73m² * severe liver cirrhosis (Child-pugh C) * severe acidosis (pH \< 7,20 at study enrolment) * severe hyperkalaemia (\> 6mmol/l) * Pregnancy or breastfeeding * persons held in an institution by legal or official order * Dependency on the investigator or center

Primary outcome measure(s)

Number of days alive and free from CRRT — Between Randomization and day 28

Trial sites (2)

Facility	City	Region	Status
University Hospital Münster	Münster	Germany	Recruiting
Universitätsklinikum Tübingen; Universitätsklinik für Anästhesiologie und Intensivmedizin	Tübingen	Germany	Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06021288 on ClinicalTrials.gov ↗ ← All trials in Germany