Critically ill patients are at risk of developing a sudden decrease of kidney function which may be detected by a decrease in urine output or is diagnosed on the basis of blood tests for substances normally eliminated by the kidney, primarily creatinine.
Because it takes about 24 hours for the creatinine level to rise, even if both kidneys have ceased to function, better markers are needed.
This trial is investigating if the marker urinary dickkopf-3 (uDKK3) allows an early prediction of a sudden decrease of kidney function.
Eligibility
Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria:
* Patients treated on the intensive care units of Saarland University Hospital.
Exclusion Criteria:
* Patients on renal replacement treatment before admission to the intensive care unit.
* Patients with chronic kidney disease stage CKD G3b or below.
* Known kidney disease.
* Kidney transplantation.
* Intoxications leading to dialysis treatment.
* Participation in other clinical trials.
Primary outcome measure(s)
Urinary dickkopf-3 — Throughout observational period, defined as timeframe from admission to intensive care unit up to two years after. Urinary dickkopf-3
Estimated Glomerula Filtration Rate — Throughout observational period, defined as timeframe from admission to intensive care unit up to two years after. Estimated Glomerula Filtration Rate by CKD-EPI-formula.
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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