Immune Modulation by Exosomes in COVID-19

NCT05191381 · tracked via the Priya Life Science Germany tracker

Sponsor

University of Ulm

Phase

Observational

Started

2021-12-22

Last updated

2024-01-17

Condition(s) studied

COVID-19Critical IllnessHypercytokinemiaLung Fibrosis

Investigational drug(s) / intervention(s)

Application of exosomes in a whole blood assay

Application of exosomes in a whole blood assay: Co-incubation of patient-derived whole blood samples with mesenchymal stem cell derived exosomes and read-out of biomarkers, RNA and immune phenotypes after 24h.

Study summary

Following whole blood stimulation with mesenchymal stem cell derived exosomes, immune phenotype, cytokine release and mRNA expression patterns from critically ill patients with COVID-19 will be determined.

Eligibility

Sex

ALL

Min age

18 Years

Max age

90 Years

Healthy volunteers

Accepted

Inclusion Criteria: * Critically ill COVID-19 patients with lung dysfunction * COVID-19 WHO severity degree \>= 4, ARDS (WHO Definition 13 March 2020) * Body weight \> 50 kg * Informed consent Exclusion Criteria: * Pregnant or breast feeding women

Primary outcome measure(s)

Cytokine profile in supernatants — 24 hours, 1 year
Quantification of pro- and anti-inflammatory biomarkers after 24 hours of whole blood culture

Trial sites (1)

Facility	City	Region	Status
Ulm University Hospital, Clinic of Anesthesiology and Intensive Care Medicine	Ulm	Germany	Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT05191381 on ClinicalTrials.gov ↗ ← All trials in Germany