Metabolomics Study on Postoperative Intensive Care Acquired Muscle Weakness

NCT03810768 · tracked via the Priya Life Science Germany tracker

Sponsor

Technical University of Munich

Phase

Observational

Started

2022-09-02

Last updated

2026-03-03

Condition(s) studied

MetabolomicsCritical CareCritical IllnessCritical Illness MyopathyCritical Illness PolyneuropathyIntensive Care (ICU) MyopathyMuscle Weakness

Study summary

In this mono-center pilot trial, surgical patients who are at high risk to be admitted to intensive care will be screened and asked for participation. We are going to take blood and muscle samples at respecified time points to do metabolic, histological and molecular testing.

Aim of the study is to investigate (1) changes of the blood metabolome in patients with ICUAW (intensive care unit acquired weakness) and (2) identify metabolic components who are responsible for ICUAW or can be used as marker for ICUAW.

Eligibility

Sex

ALL

Min age

18 Years

Max age

—

Healthy volunteers

Inclusion Criteria: * invasive mechanically ventilated critically ill patient with expected intensive care unit stay \> 3 days * postoperative patient * ≥ 18 years old * American Society of Anesthesiology (ASA) classification ≥ III Exclusion Criteria: * moribund patient * non-curative care (comfort care)

Primary outcome measure(s)

Metabolomics — a median of 14 days
Blood Metabolome will be isolated from blood samples. All samples will be screened for influence of Intensive Care Unit Acquired Weakness (ICUAW) using mass spectrometry.

Trial sites (3)

Facility	City	Region	Status
Medical University of Vienna	Vienna	State of Vienna	Recruiting
Klinikum rechts der Isar, School of Medicine, Technical University of Munich	Munich	Bavaria	Active Not Recruiting
Charité - Universitätsmedizin Berlin	Berlin	State of Berlin	Active Not Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT03810768 on ClinicalTrials.gov ↗ ← All trials in Germany