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Clinical Trials in Egypt / NCT07823972
Starting soon Not applicable

Dapagliflozin and Right Heart Recovery After ASD Device Closure

NCT07823972 · tracked via the Priya Life Science Egypt tracker
Phase
Not applicable
Started
2026-11-01
Last updated
2026-09-17

Condition(s) studied

ASD2(Secundum Atrial Septal Defect)

Investigational drug(s) / intervention(s)

trans catheter device closure

trans catheter device closure: randomized clinical trila

Study summary

The aim of this study is to evaluate the clinical and echocardiographic influence of dapagliflozin on right ventricular reverse remodeling in adult patients following successful transcatheter Atrial Septal Defect (ASD) device closure.

Eligibility

Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
Accepted
Inclusion Criteria: \- 1. Adults with ASD and significant left to right shunt which is anatomically suitable for transcatheter device closure. 2\. Adults (age ≥18 years) of both genders. 3. Sinus rhythm on presentation. Exclusion Criteria: * 1\. Presence of other congenital anomalies e.g. AV canal, CoA, VSDs, PDA, dextrocardia. 2\. Significant irreversible pulmonary hypertension (PVR ≥ 5 wood units) or Eisenmenger syndrome. 3\. Patients presented with arrythmias (especially atrial fibrillation). 4. Severe left ventricular systolic dysfunction (LV ejection fraction (\< 50%). 5. Significant Valvular Heart Disease. 6. Patients known to have history of ischemic heart disease or percutaneous coronary interventions. 7\. Severely impaired renal function defined as an estimated glomerular filtration rate (eGFR) (\< 30 mL/min/1.73m²) 8. Patients with contraindications for SGLT2i: Type 1 diabetes mellitus, history of diabetic ketoacidosis, recurrent severe urinary tract infections, active genital mycotic infections, or known hypersensitivity to dapagliflozin. 9\. Poor-quality Echocardiography images precluding strain analysis

Primary outcome measure(s)

Trial sites (1)

FacilityCityRegionStatus
Assiut university Asyut Egypt

More Assiut University trials in Egypt

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07823972 on ClinicalTrials.gov ↗ ← All trials in Egypt