Osteoarthritis (OA) and sarcopenia are two highly prevalent, interconnected geriatric syndromes that often coexist, leading to a condition termed "osteosarcopenia". Globally, the pooled prevalence of sarcopenia in patients with knee OA is estimated at approximately 25.07%, significantly higher than in the general population.
Eligibility
Sex
ALL
Min age
40 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria:
* Adults aged 40 years and older diagnosed with knee OA based on the American College of Rheumatology (ACR) criteria.
* Patients who are willing to participate and provide informed written consent.Exclusion Criteria:
* Inflammatory arthritis: patients with rheumatoid arthritis, gouty arthritis, or systemic lupus erythematosus (SLE) to avoid confusion with inflammatory muscle wasting.
* Physical Limitations: amputees or those with severe physical deformities preventing gait speed tests or handgrip measurement.
* Patients with cardiac pacemakers or implanted electronic devices (as these interfere with Bioelectrical Impedance Analysis (BIA)).
* Severe Comorbidities: end-stage renal or hepatic disease, advanced malignancy or cachexia.
* Severe neurological disorders (e.g., Parkinson's disease, Stroke with paralysis) that directly affect muscle mass and mobility.
* Prolonged use of systemic corticosteroids (which cause secondary sarcopenia)
Primary outcome measure(s)
Prevalence of sarcopenia in knee osteoarthritis patients — at baseline Prevalence of OA patients who meet the diagnostic criteria for sarcopenia (low muscle mass, strength, and physical performance) according to the European Working Group on Sarcopenia in Older People (EWGSOP2) revised consensus.
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
We use cookies to analyse site traffic and improve your experience. With your consent, we may also use cookies for advertising. You can change your choice at any time.