Total Intravenous and Balanced Anesthesia in Diabetic Patients Undergoing Video-Assisted Thoracoscopy

NCT07496593 · tracked via the Priya Life Science Egypt tracker

Sponsor

Ain Shams University

Phase

Phase 4

Started

2025-12-01

Last updated

2026-03-27

Condition(s) studied

Diabete MellitusVATSTIVA

Investigational drug(s) / intervention(s)

Propofol + fentanyl + AtracuriumAll Propofol trials (76) →All Fentanyl trials (31) →All Atracurium trials (2) →Isoflurane and Atracurium

Propofol + fentanyl + Atracurium: Group A (TIVA) will not receive any inhaled anesthesia

Isoflurane and Atracurium: Group B will receive inhaled anesthesia

Study summary

Video-assisted thoracoscopy is a minimally invasive surgical technique used to diagnose and treat problems in chest. Diabetics are more prone to infections, slower wound healing and other complications during and after surgery. Studies suggests that Total Intravenous Anesthesia (TIVA) can lead to a lower increase in blood glucose levels and a better suppression of the stress response compared to balanced anesthesia using inhalational agents like Isoflurane.

In the present study we are aiming to compare the effects of Total Intravenous Anesthesia (TIVA) Versus Balanced Anesthesia on blood glucose level in Diabetic Patients undergoing Video-assisted thoracoscopy.

Eligibility

Sex

ALL

Min age

18 Years

Max age

70 Years

Healthy volunteers

Inclusion Criteria: * Patient for both sex scheduled for VATS. * Age group 18-70 years. * Diagnosed diabetes mellitus (Type 1 or 2) HbA1c 6-8 % within 3 months. * ASA II and III. Exclusion Criteria: * HbA1c \> 8 % or \< 6 or preoperative insulin infusion or DKA within 3 months * Emergency surgery. * Drug allergy. * Chronic high-dose steroids. * Severe hepatic/ renal impairment, significant arrhythmia or severe LV dysfunction. * Patient refusal. * Psychiatric illness.

Primary outcome measure(s)

The primary outcome of this study will be blood glucose level after one and half hour — one and half hour
measurement of blood gulcose level

Trial sites (1)

Facility	City	Region	Status
Ain Shams University	Cairo	Abasya

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07496593 on ClinicalTrials.gov ↗ ← All trials in Egypt