Dexmedetomidine: micro dose of dexmedetomidine (0.3 µg /kg) in 50 ml 0.9% saline slow infusion over 10 minutes, 15 minutes before surgery.
Saline: 50 ml 0.9% saline slow infusion over 10 minutes, 15 minutes before surgery.
Study summary
This prospective randomized controlled study will be conducted to evaluate the effect of preoperative single, micro-dose of dexmedetomidine (0.3μg/kg) on the incidence and severity of EA in adults undergoing Septoplasty surgeries
Eligibility
Sex
ALL
Min age
18 Years
Max age
60 Years
Healthy volunteers
No
Inclusion Criteria:
* Adult patients of both gender aged 18 to 60 years with American Society of Anesthesiologists (ASA) Physical Status I or II, who were scheduled for septoplasty surgery under general anesthesia.
Exclusion Criteria:
* Patients declined to participate in the trial.
* History or clinical evidence of chronic obstructive pulmonary disease.
* History of renal or hepatic dysfunction, sleep apnea syndrome.
* Cognitive dysfunction or psychiatric disorder.
* Patients receiving beta blocker.
* Patients with anticipated difficult airway.
* Patients with electro cardiac abnormalities.
* Emergency surgeries.
* Pregnancy.
Primary outcome measure(s)
Incidence of emergence agitation — incidence of emergence agitation will be assessed by Aono's Four-point Scale (AFPS) after extubation, at PACU arrival, every 5 minutes for the first 15 minutes then every 15 minutes for the first hour after surgery. using Aono's Four-Point Scale (Aono Scale) which is a simple and widely used tool to assess emergence agitation (EA). It categorizes agitation during emergence from anesthesia into four levels.
1. calm\_ Patient is quiet and not agitated.
2. Not calm but can be easily consoled \_ Slight restlessness but settles with verbal reassurance or mild physical comfort.
3. Moderately agitated \_ Patient is crying or difficult to console but not combative.
4. Severely agitated \_Patient is thrashing, inconsolable, or combative, and poses risk of injury to self or staff.
Scores 3-4 indicate clinically relevant emergence agitation.
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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