Evaluation of Cytokines Level as an Indicator of Pulp Inflammation and Its Relation to the Success Rates of Pulpotomy in Primary Molars Affected With Proximal Versus Occlusal Decay
Pulpotomy: * Local anesthesia will be administered, and the tooth will be isolated with a rubber dam.
* To minimize further bacterial contamination, carious tissues will be removed progressively, starting from the cavity periphery and then over the pulp chamber roof.
* Before managing the pulpal hemorrhage, a sterile cotton pellet will be placed over the pulp tissue for 30-45 s.
* A fresh sterile bur will be used to remove all coronal pulp tissue down to the root canal orifices, with copious water irrigation
* MTA will be used as medicament of choice for pulpotomy.
* The pulpotomy-treated tooth will be prepared to receive a full-coverage stainless steel crown (SSC) after the procedure.
Measuring Cytokines level: measuring cytokines level as an indicator for pulp inflammation
Study summary
pulpotomy will be done I primary molars with occlusal or proximal decay and level of cytokines will be measured as an indicator for pulp inflammation levels
Eligibility
Sex
ALL
Min age
4 Years
Max age
9 Years
Healthy volunteers
No
Inclusion Criteria:
* Children with provoked pain.
* Caries in proximal surface to the dentine full thickness.
* Caries in occlusal surface to the dentine full thickness.
* Radicular pulp health is verified by achieving hemostasis within eight minutes of compression using a cotton pellet with 5% sodium hypochlorite.
Exclusion Criteria:
* Unrestorable primary molars.
* Primary molars with spontaneous pain.
* Medically compromised patients who have systemic disease.
* Uncooperative children who refuse treatment.
* Children whose parents are unwilling to place stainless steel crowns.
* Children whose parents or caregivers refuse to participate in the study or are unable to attend follow-up visits.
Primary outcome measure(s)
Post operative Pain — pain will be measured at one week , 3 months , 6 months and 12 months. The Visual Analogue Scale (VAS) measures pain intensity. The VAS consists of a 10cm line, with two end points representing 0 ('no pain') and 10 ('pain as bad as it could possibly be').
Ask the patient to rate their current level of pain by placing a mark on the line. Use a ruler to measure the distance in centimetres from the 'no pain marker' (or zero) to the current pain mark. This provides a pain intensity score out of 10; for example, 6 out of 10 (or 6/10).
Preapical lesion — will be measured at 3 months , 6 months and 12 months by Clinical examination: presence of Swelling, sinus tract, or fistula: ,(binary outcome: present or absent )
Pain on percussion — will be measured at 3 months , 6 months and 12 months Tapping the tooth with the blunt end of the mirror binary outcome: present or absent
Mobility — will be measured at 3 months , 6 months and 12 months using Miller's mobility test :involves holding the tooth firmly between two instruments and assessing its mobility on a scale from 0 to 3. A score of 0 indicates no detectable movement, while scores of 1-3 represent increasing degrees of mobility.
it will be measured as present for any score from 1 to 3 (binary: present or absent)
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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