Impact of Isoflurane and Sevoflurane on Oxidative Stress in Patients Undergoing Laparoscopic Cholecystectomy

NCT07152912 · tracked via the Priya Life Science Egypt tracker

Sponsor

Ain Shams University

Phase

Not applicable

Started

2025-09-04

Last updated

2025-09-05

Condition(s) studied

IsofluraneSevofluraneOxidative StressLaparoscopic Cholecystectomy

Investigational drug(s) / intervention(s)

Isoflurane →Sevoflurane →

Isoflurane: Patients will receive general anesthesia and maintenance by isoflurane.

Sevoflurane: Patients will receive general anesthesia and maintenance by sevoflurane.

Study summary

The primary aim of this work is to assess the impact of exposure to isoflurane or sevoflurane as an inhalation anesthetic on the oxidative stress and inflammatory conditions in patients undergoing elective moderate invasive surgery (laparoscopic cholecystectomy).

Eligibility

Sex

ALL

Min age

20 Years

Max age

60 Years

Healthy volunteers

Inclusion Criteria: * Age from 20 to 60 years. * Both sexes. * American Society of Anesthesiologists (ASA) Physical Status I-II. * Undergoing elective laparoscopic cholecystectomy under general anesthesia. Exclusion Criteria: * Refusal of participation in the study by patients. * Diabetes (type I or II), endocrine system, and immune system diseases. * Chronic infection and sepsis. * Cardiac condition as classified bythe New York Heart Association (NYHA) \> class II. * Hepatic disease: INR \> 1.5, and/or albumin \< 2.5 g/dL. * Renal disease: glomerular filtration rate (GFR) \< 85 ml/min. * Mental and neurological disorders.

Primary outcome measure(s)

Serum level of superoxide dismutase — 6 months postoperatively
Serum level of superoxide dismutase (SOD) will be recorded.

Trial sites (1)

Facility	City	Region	Status
Ain Shams University	Cairo	Egypt	Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07152912 on ClinicalTrials.gov ↗ ← All trials in Egypt