A Comparative Study of Combined Adductor Canal and Interspace Between Popliteal Artery and Knee Capsule Versus Combined Adductor Canal and Genicular Nerve in Total Knee Arthroplasty

NCT06864663 · tracked via the Priya Life Science Egypt tracker

Sponsor

Ain Shams University

Phase

Not applicable

Started

2025-03-15

Last updated

2025-03-07

Condition(s) studied

Nerve BlockRegional Anaesthesia

Investigational drug(s) / intervention(s)

nerve block with bupivacaine 0.25% →Nerve Block with bupivacaine 0.25% →

nerve block with bupivacaine 0.25%: ultrasound guided adductor canal block and interspace between the popliteal artery and the knee capsule using bupivacaine 0.25%

Nerve Block with bupivacaine 0.25%: ultrasound guided combined adductor canal block and genicular nerve block using bupivacaine 0.25%

Study summary

The aim of this study is to investigate the effectiveness of combined adductor canal block (ACB) with interspace between popliteal artery and the knee capsule (IPACK) versus combined ACB with genicular nerve block (GNB) for providing analgesia in knee arthroplasty. The investigators hypothesize that the analgesic efficacy of ACB combined with GNB will be non-inferior to that of ACB combined with IPACK. Additionally, the investigators aim to assess whether the combination of ACB and GNB results in a significantly lower occurrence of sensory or motor block affecting the tibial and common peroneal nerves compared to ACB and IPACK

Eligibility

Sex

ALL

Min age

18 Years

Max age

70 Years

Healthy volunteers

Inclusion Criteria: 1. Patients American Society of anesthesiologists' physical status (ASA) I to III. 2. Aged 18 to 70 years. 3. Both sexes. 4. Patients scheduled for total knee arthroplasty. Exclusion Criteria: 1. Patient refusal 2. ASA physical status IV or more. 3. Patients with known allergy to any of the study drugs. 4. Infection at the site of injection. 5. Patients with neuromuscular disease. 6. Presence of any coagulopathy. 7. Patients with history of any psychiatric or cognitive disorder. 8. patient with previous knee surgery. 9. BMI more than 40 kg/m2.

Primary outcome measure(s)

individual visual analog pain scores at 0, 6, 12 , 24 and 48 h postoperatively — 48 hours
(VAS; 0 = no pain and 10 = worst pain imaginable)

Trial sites (1)

Facility	City	Region	Status
Ain Shams University	Cairo	Egypt

More Ain Shams University trials in Egypt

Iliopsoas Nerve Block and Femoral Nerve Block in Hip Fracture Surgeries Recruiting

Comparative Study Between Pericapsular Nerve Group Block (PENG) And Pericapsular Nerve Group (PENG) Block Combined With Lateral Femoral Cutaneous Nerve (LFCN) Block for Positioning Analgesia Prior to Spinal Anesthesia in Hip Fracture Patients Recruiting

Neutrophils to Lymphocytes and Platelets Ratio, Procalcitonin, and Total Leucocytic Count as Indicators of Prognostic Outcome in Septic Patients in the Intensive Care Unit. Recruiting

Palmitoylethanolamide in Ulcerative Colitis Recruiting

Assessment of Oral Caffeine Intake in Changing the Severity of Acute Migraine Attack Using VAS Score Among Patients Attending Headache and Neurology Outpatients Clinic of Ainshams University Hospitals Recruiting

Other trials for the same condition

TIPS Block vs. IV Analgesia for Postoperative Pain After Knee Arthroscopy Starting soon

Ultrasound-Guided Infraclvicular Block Using Dexmedetomidine Versus Nalbuphine as Adjuvants to Bupivacaine in Upper Limb Orthopedic Surgery Starting soon

Erector Spinae Plane Block Versus Lateral Transversus Abdominis Plane Block for Open Abendectomy Surgery Recruiting

Comparison Between Ultrasound Guided Quadratus Lumborum Block and Erector Spinae Plane Block as an Analgesic Modality in Renal Transplant Donors Active, not recruiting

Ultrasound Guided External Oblique Intercostal Plane Block Versus Erector Spinae Block for Post Hepatectomy Pain Starting soon

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06864663 on ClinicalTrials.gov ↗ ← All trials in Egypt