Optimal Meals to Reduce Bone Resorption in Women With Osteopenia

Condition(s) studied

Investigational drug(s) / intervention(s)

200 ml dairy: Participants consume the meal after a fasting baseline bloodsample. Bloodsamples are collected over a six-hour period to evaluate postpandrial changes in bone turnover markers.

100 ml milk: Participants consume the meal after a fasting baseline bloodsample. Bloodsamples are collected over a six-hour period to evaluate postpandrial changes in bone turnover markers.

100 g banana: Participants consume the meal after a fasting baseline bloodsample. Bloodsamples are collected over a six-hour period to evaluate postpandrial changes in bone turnover markers.

100 ml dairy and fibers: Participants consume the meal after a fasting baseline bloodsample. Bloodsamples are collected over a six-hour period to evaluate postpandrial changes in bone turnover markers.

Fasting (control): Participants consume the meal after a fasting baseline bloodsample. Bloodsamples are collected over a six-hour period to evaluate postpandrial changes in bone turnover markers.

100 ml dairy: Participants consume the meal after a fasting baseline bloodsample. Bloodsamples are collected over a six-hour period to evaluate postpandrial changes in bone turnover markers.

Study summary

The goal of this clinical trial is to investigate whether different types of small meals can help reduce bone loss in postmenopausal women with osteopenia, a condition where bone density is lower than normal and may lead to osteoporosis.

The main hypothesis is:

\- A small amount of dairy (100 ml) is just as effective as a larger meal containing dairy and banana in reducing bone resorption.

Based on this, the study aims to answer the following questions:

\- Which type and size of meal is most effective in reducing bone resorption?

Researchers will compare five different types of meals to a fasting control day to determine which meals best reduce markers of bone loss in the blood.

Participants will attend six clinical visits: five involving the intake of different test meals, and one control visit involving fasting. The participants will have blood samples taken over a period of 6 hours after each meal or fasting period to measure markers of bone metabolism.

This study aims to identify a simple, non-drug-based strategy to support bone health and help prevent progression to osteoporosis.

Eligibility

Primary outcome measure(s)

• Bone resoroption — From enrollment through six study visits over a period of approximately 12 weeks
  The primary endpoint of the study is difference in the area under curve of the bone resorption marker CTX during the different study days

Trial sites (1)

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