Danish Angle Closure Prevention Trial

Condition(s) studied

Investigational drug(s) / intervention(s)

Iridotomy: Peripheral iridotomy (size \>200µm)

Study summary

To determine whether primary angle closure suspects (PACS) in a Caucasian population benefit from prophylactic laser iridotomy.

Eligibility

Primary outcome measure(s)

• Intraocular pressure — 5 year
  GAT: ≥24mmHg or ≥22mmHg on two separate occasions
• Glaucoma — 5 year
  The presence of glaucomatous optic neuropathy with visual field loss compatible with glaucoma. Glaucomatous optic neuropathy defined as loss of neuroretinal rim (notch or erosion), a vertical cup-to-disc ratio of more than 0.7, nerve fiber layer defect attributable to glaucoma, or both.
• Acute Primary Angle Closure — 5 year
  Presence of at least 2 of the following symptoms: ocular or periocular pain; nausea, vomiting, or both; an antecedent history of intermittent blurring of vision with haloes and IOP of more than 30 mmHg and presence of at least 3 of the following signs: conjunctival injection, corneal epithelial edema, mid-dilated unreactive pupil, glaukomflecken, and shallow anterior chamber;

Trial sites (5)

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