The Ventilation During In-hospital Cardiac Arrest Study

Condition(s) studied

Investigational drug(s) / intervention(s)

Positive pressure ventilation during cardiopulmonary resuscitation: The primary exposures of interest are the observed ventilation rate, tidal volume and minute ventilation during cardiopulmonary resuscitation. Ventilation data are obtained by inspiratory and expiratory air flow measurements using the EOlife (Archeon, Besançon, France) to which healthcare providers are blinded.

Study summary

The goal of this prospective observational study is to learn how ventilation quality parameters during cardiopulmonary resuscitation (CPR) are associated with short-term survival following in-hospital cardiac arrest of adult patients.

The main questions it aims to answer are:

What ventilation volume during CPR is associated with the highest chance of return of spontaneous circulation (ROSC)? What ventilation rate during CPR is associated with the highest chance of ROSC?

Researchers will compare different levels of ventilation rates and volumes that are blindly measured during CPR to see how the observed rates and volumes are associated with survival outcomes and complications.

Eligibility

Primary outcome measure(s)

• Fraction of patients with return of spontaneous circulation (ROSC) — ROSC is assessed immediately following cardiopulmonary resuscitation.
  ROSC is defined as sustained spontaneous circulation with no need for chest compressions for at least 20 minutes.

Trial sites (11)

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