Real-time quaking-induced conversion (RT-QuIC): RT-QuIC measures the ability of alpha-synuclein (aSyn) to misfold other aSyn proteins and is an amplification technique.
Cognitive test: Minimal Mental State examination (MMSE), Montreal Cognitive Assessment (MoCA)
Motor examination: Unified Parkinsons Rating Scale (UPDRS)
Study summary
This a study to improve diagnosis of dementia with Lewy bodies with RT-QuIC in different biospecimens.
Eligibility
Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
Accepted
Inclusion criteria for healthy controls (HC):
* Age 18 - 40 years of age
* Able to cooperate as evaluated by the primary investigator (PI)
* Able to give informed consent
Exclusion criteria
* Signs of neurological/psychiatric conditions
* Known genetic neurodegenerative disease in close family
Inclusion criteria for patients with Dementia with Lewy Bodies (DLB):
* Probable DLB (McKeith et al., 2017) or MCI-LB (McKeith et al., 2020)
* Age \> 50 years of age
* Able to give informed consent
* Able to cooperate as evaluated by the PI
* MCI, mild or moderate dementia, and MMSE \> 18
Exclusion criteria for patients with DLB:
* Patients not able to give informed consent.
* Current alcohol or drug abuse
* Terminal illness
* Diagnosed with major neurological/psychiatric conditions other than DLB.
Inclusion criteria for controls (patients with Alzheimer's disease (AD)):
* Probable AD (McKhann et al., 2011) or MCI-AD (Albert et al., 2011)
* Age \> 50 years of age
* Able to give informed consent
* Able to cooperate as evaluated by the PI
* MCI, mild or moderate dementia, and MMSE \> 18
Exclusion criteria for controls (patients with AD):
* Patients not able to give consent.
* Current alcohol or drug abuse
* Terminal illness
* Diagnosed with major neurological/psychiatric conditions other than AD.
Primary outcome measure(s)
Diagnostic accuracy of Real-time quaking-induced conversion — 24 months Specificity
Diagnostic accuracy of Real-time quaking-induced conversion — 24 months Sensitivity
Diagnostic accuracy of Real-time quaking-induced conversion — 24 months Area under the curb
Trial sites (1)
Facility
City
Region
Status
Danish Dementia Research Centre
Copenhagen
Denmark
More Danish Dementia Research Centre trials in Denmark
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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