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Clinical Trials in Denmark / NCT05768425
Active, not recruiting Observational

DIagnostic Biomarkers and Symptoms in Patients With Alzheimer's Disease and Lewy bodY Dementia

NCT05768425 · tracked via the Priya Life Science Denmark tracker
Phase
Observational
Started
2023-02-01
Last updated
2023-10-10

Condition(s) studied

Dementia With Lewy BodiesAlzheimer DiseaseMild Cognitive Impairment

Investigational drug(s) / intervention(s)

Real-time quaking-induced conversion (RT-QuIC)Cognitive testMotor examination

Real-time quaking-induced conversion (RT-QuIC): RT-QuIC measures the ability of alpha-synuclein (aSyn) to misfold other aSyn proteins and is an amplification technique.

Cognitive test: Minimal Mental State examination (MMSE), Montreal Cognitive Assessment (MoCA)

Motor examination: Unified Parkinsons Rating Scale (UPDRS)

Study summary

This a study to improve diagnosis of dementia with Lewy bodies with RT-QuIC in different biospecimens.

Eligibility

Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
Accepted
Inclusion criteria for healthy controls (HC): * Age 18 - 40 years of age * Able to cooperate as evaluated by the primary investigator (PI) * Able to give informed consent Exclusion criteria * Signs of neurological/psychiatric conditions * Known genetic neurodegenerative disease in close family Inclusion criteria for patients with Dementia with Lewy Bodies (DLB): * Probable DLB (McKeith et al., 2017) or MCI-LB (McKeith et al., 2020) * Age \> 50 years of age * Able to give informed consent * Able to cooperate as evaluated by the PI * MCI, mild or moderate dementia, and MMSE \> 18 Exclusion criteria for patients with DLB: * Patients not able to give informed consent. * Current alcohol or drug abuse * Terminal illness * Diagnosed with major neurological/psychiatric conditions other than DLB. Inclusion criteria for controls (patients with Alzheimer's disease (AD)): * Probable AD (McKhann et al., 2011) or MCI-AD (Albert et al., 2011) * Age \> 50 years of age * Able to give informed consent * Able to cooperate as evaluated by the PI * MCI, mild or moderate dementia, and MMSE \> 18 Exclusion criteria for controls (patients with AD): * Patients not able to give consent. * Current alcohol or drug abuse * Terminal illness * Diagnosed with major neurological/psychiatric conditions other than AD.

Primary outcome measure(s)

Trial sites (1)

FacilityCityRegionStatus
Danish Dementia Research Centre Copenhagen Denmark

More Danish Dementia Research Centre trials in Denmark

Other trials for the same condition

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT05768425 on ClinicalTrials.gov ↗ ← All trials in Denmark