PRP Injection: Endoscopic balloon dilatation combined with autologous platelet-rich plasma (PRP) injection with different concerntrations
Study summary
The aim was to investigate whether endoscopic balloon dilatation combined with PRP injection can help prevent or prolong restenosis in patients with Crohn's disease with colonic stenosis, and to explore the concentration of PRP. The study was a single-center, randomized, non-controlled study. Experimental group of patients underwent endoscopic balloon dilation and submucosal injection of PRP at the wound edge, historical control was used, and the patients included in the study were randomly divided into high concentration group and low concentration group.
Eligibility
Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria:
* Diagnosed as CD;
* Stenosis of the colon was found during colonoscopy, and surgery was not considered for the time being; ③ Narrow length \<5cm; ④ The patients agreed to undergo endoscopic balloon dilatation and voluntarily signed the informed consent to participate in this study, and were capable of complying with the agreement.
Exclusion Criteria:
* The patient has contraindications for endoscopic therapy, such as coagulation disorder, severe cardiopulmonary dysfunction, active bleeding, and inability to cooperate.
* Deep and large active ulcer was found in the stenosis;
* \< 18 years old;
* Foreign patients;
* Patients with a history of malignant tumors, including melanoma (except local skin cancer);
* Pregnant or nursing patients;
* Patients who could not be followed at all nodes of the primary outcome indicator; Other diseases that researchers believe could put patients at risk;
* Other diseases that researchers believe could put patients at risk.
Primary outcome measure(s)
restenosis rate — 3 months after endotherapy restenosis means the endoscopy with size of 10.5mm can not pass the stricture afer endotherapy
Trial sites (1)
Facility
City
Region
Status
The Sixth Affiliated Hospital, Sun Yat-sen University
Guangzhou
Guangdong
More Sixth Affiliated Hospital, Sun Yat-sen University trials in China
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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