The Effect of Remote Ischemic Preconditioning on Myocardial Injury After Noncardiac Surgery

Condition(s) studied

Investigational drug(s) / intervention(s)

Remote ischemic preconditioning: Remote ischemic preconditioning will consist of four cycles of 5-minute inflation of an blood pressure cuff on the upper arm to 200 mmHg followed by 5-minute deflation. RIPC will be performed twice, one at approximately 24 hours before anaesthesia and the other at approximately 1 hour before anaesthesia.

Sham-remote ischemic preconditioning: The identical looking cuff will be placed around the upper arm but not actually inflated for 40 minutes. The control device's components and external appearance are identical to that of the RIPC. However, as compared to the RIPC, the blood pressure cuff's line of inflation is disconnected such that the cuff cannot be inflated. Control treatment will be performed twice, one at approximately 24 hours before anaesthesia and the other at approximately 1 hour before anaesthesia.

Study summary

This is a multicentre, parallel-group, randomised, sham-controlled, observer blinded trial, assessing the efficacy of remote ischemic preconditioning on preventing myocardial injury after noncardiac surgery.

Eligibility

Primary outcome measure(s)

• Myocardial injury after non-cardiac surgery (MINS) — Within the first three days after surgery
  Number of participants with MINS, diagnosed according to the criteria established by the American Heart Association in 2021

Trial sites (1)

More Sixth Affiliated Hospital, Sun Yat-sen University trials in China

Other trials for the same condition