Independent and Combined Effects of Short-term Sulforaphane Supplementation and Exercise on Immunometabolism in Healthy Adults

NCT07668596 · tracked via the Priya Life Science Canada tracker

Sponsor

University of British Columbia

Phase

Not applicable

Started

2026-03-01

Last updated

2026-07-17

Condition(s) studied

ImmunometabolismMitochondrial Function, BioenergeticsInflammation

Investigational drug(s) / intervention(s)

Sulforaphane-rich Broccoli Sprout ExtractHigh Intensity Interval Treadmill Running

Sulforaphane-rich Broccoli Sprout Extract: Broc Elite Plus stabilized sulforaphane capsules from Mara Labs

High Intensity Interval Treadmill Running: 4 cycles of: 4 minutes of intense treadmill running (85-95% HR max) followed by 3 minutes of slow, easy running.

Study summary

The study consist of 3 interventional periods which will be completed by each consenting participant in a randomized, crossover fashion. The interventional periods will be separated by a minimum 1 week washout period. One of the interventions consists of 4 days of daily supplementation with the commercially available broccoli sprout extract capsules (BrocElite). Another intervention will consist of 4 days of daily supervised treadmill running. The exercise protocol consists of 4 minutes of high-intensity running running followed by a 3 minute recovery period, repeated for a total of 4 repetitions. The last intervention combines the above two and consists of 4 days of daily supplementation and daily supervised exercise training. Before and after each intervention, basic anthropometrics (weight, heart rate, and blood pressure) will be recorded, and a venous blood sample will be collected. Blood samples will be analyzed for metabolic and inflammatory markers. Participants will be asked to refrain from structured exercise, alcohol consumption, and broccoli consumption during each of the experimental periods. Before any testing, willing participants will provide informed consent, and fill out a few demographic, and lifestyle questionnaires. The study will be conducted at the University of British Columbia in Kelowna, BC, Canada.

Eligibility

Sex

ALL

Min age

19 Years

Max age

35 Years

Healthy volunteers

Accepted

Inclusion Criteria: * aged between 19 and 35 years * not a current smoker * physically active based on the Canadian Physical Activity Guidelines (150 minutes of weekly physical activity) Exclusion Criteria: * a history of cardiometabolic diseases or respiratory diseases (e.g., chronic obstructive pulmonary disease, asthma, diabetes, coronary artery disease) * currently following a ketogenic diet * body mass index (BMI) over 30 kg/m2 * unable to read or communicate in English * having received a vaccination or experienced an upper respiratory tract infection in the last 4 weeks * having donated more than 0.5 L of blood within the last 4 weeks * currently pregnant * have contraindications to high intensity exercise (assessed using the CSEP Get Active Questionnaire)

Primary outcome measure(s)

Change in peripheral blood mononuclear cell oxygen consumption rate — 0-4 days
OCR will be measured using a Seahorse Analyzer before and after each 4-day intervention

Trial sites (1)

Facility	City	Region	Status
Reichwald Health Sciences Centre	Kelowna	British Columbia	Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07668596 on ClinicalTrials.gov ↗ ← All trials in Canada