Studying the Effects of Cannabis on Vasculature

NCT05581368 · tracked via the Priya Life Science Canada tracker

Sponsor

London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

Phase

Observational

Started

2023-12-01

Last updated

2025-06-15

Condition(s) studied

Cardiovascular DiseasesInflammationAtherosclerosis

Investigational drug(s) / intervention(s)

Chronic Cannabis use

Chronic Cannabis use: The investigators will test levels of inflammation and vascular dysfunction in participants who chronically use cannabis.

Study summary

Cannabis is commonly used globally. It is associated with psychiatric problems, but the effects on the cardiovascular system are unclear. In this project, the investigators plan to study the effects of cannabis on the cardiovascular system. This will be done by using a non-invasive test to measure blood vessel function and by using blood samples to measure inflammation. As a control for this project, the investigators would like to test the blood vessel function and inflammation levels of participants who do not use cannabis. This study will provide important information on the long term cardiovascular effects of cannabis.

Eligibility

Sex

ALL

Min age

19 Years

Max age

80 Years

Healthy volunteers

Accepted

Inclusion Criteria: * age: 19 to 80 * males and females * all ethnicities * cannabis use at least 3-4 times per week or more in the past 6 months (50 volunteers, experimental group) * patients who do not use cannabis (50 volunteers, control group) * no history of cardiovascular disease Exclusion Criteria: * that ingest cannabis containing cannabidiol (CBD) * that are unable to provide a receipt for the cannabis product(s) they ingest * that are unwilling to stop consuming soy products and/or genistein 48 hours prior to appointments.

Primary outcome measure(s)

Inflammation — Baseline measurement.
The investigators will measure the concentration of inflammatory cytokines using an Olink for chronic cannabis users and the control group.
Endothelial function — Baseline measurement.
The investigators will measure the reactive hyperaemia index (RHI) using an EndPAT device for both groups.

Trial sites (1)

Facility	City	Region	Status
London Regional Health Science Centre	London	Ontario	Recruiting

More London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's trials in Canada

Pramipexole and the Risk of Serious Adverse Events Active, not recruiting

Fluid Intake After Hemodialysis Recruiting

Intermittent Fasting for Inflammation and Depression in Spinal Cord Injury Starting soon

Extracorporeal Photopheresis in Early Diffuse Cutaneous Systemic Sclerosis Starting soon

Ambroxol as a Novel Disease Modifying Treatment for Lewy Body Dementia Starting soon

Other trials for the same condition

Clinical Trial to Evaluate the Safety and Effectiveness of Using the Tendyne Transcatheter Mitral Valve System for the Treatment of Symptomatic Mitral Regurgitation Active, not recruiting

Effects of Increased Greek Yogurt Consumption in Youth and Young Adult Athletes Recruiting

Walk It Off! the Influence of Physical Activity Level on the Recovery from Damaging Resistance Exercise Active, not recruiting

A Study to Evaluate the Efficacy, Safety, Pharmacodynamics (PD), and Pharmacokinetics (PK) of Selnoflast in Reducing Vascular Inflammation in Participants With Atherosclerosis at Risk for Major Adverse Cardiac Events Recruiting

IAMABLE: Implementation and Evaluation of an App for Evidence-Based Self-Management Rehabilitation Strategies Recruiting

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT05581368 on ClinicalTrials.gov ↗ ← All trials in Canada