Investigation of the Association of Multimodal Neuroimaging and Peripheral Biomarkers With Executive Functions and Emotional Regulation in Adolescents With Attention-Deficit/Hyperactivity Disorder
No Intervention: This is an observational study. No intervention or treatment is assigned to participants. Participants are assessed using clinical and neuropsychological assessments, resting-state functional magnetic resonance imaging, and peripheral blood biomarker measurements.
Study summary
The purpose of this observational study is to investigate the relationships among resting-state brain connectivity, peripheral blood biomarkers, executive functions, and emotional regulation in adolescents with attention-deficit/hyperactivity disorder (ADHD). The study will include 40 adolescents aged 10 to 18 years with ADHD and 40 age- and sex-matched healthy controls. Participants will undergo clinical and psychological assessments, resting-state functional magnetic resonance imaging, and blood sampling. Serum levels of BDNF, cortisol, IL-1α, IFN-γ, TNF-α, and IL-6 will be measured. The study will examine whether differences in brain connectivity and biomarker levels are associated with executive functioning and emotional regulation.
Eligibility
Sex
ALL
Min age
10 Years
Max age
18 Years
Healthy volunteers
Accepted
Inclusion Criteria:
* Age 10-18 years, including ages 10 and 18.
* Diagnosis of attention-deficit/hyperactivity disorder (ADHD) according to DSM-5 criteria.
* Clinically normal intellectual capacity (IQ \>80).
* Predominantly right-handed.
* No acute or chronic inflammatory disease.
Healthy Control Group:
* Age 10-18 years, including ages 10 and 18.
* No psychiatric diagnosis according to DSM-5 criteria.
* Clinically normal intellectual capacity (IQ \>80).
* Predominantly right-handed.
* No acute or chronic inflammatory disease.
Exclusion Criteria:
* Age younger than 10 or older than 18 years.
* Intellectual disability (IQ \<80).
* Hydrocephalus or herniation.
* Predominantly left-handed.
* History of possible traumatic brain injury.
* Current or past neurological or serious medical disease (e.g., epilepsy).
* Autism spectrum disorder.
* Psychotic disorder.
* Mood disorder.
* Conduct disorder.
* Active anxiety disorder or substance use disorder.
* Presence of an acute or chronic inflammatory disease.
Primary outcome measure(s)
Resting-State Functional Connectivity Within and Between the Default Mode Network and Other Brain Networks — At the baseline assessment Resting-state functional magnetic resonance imaging (fMRI) will be used to assess functional connectivity within the Default Mode Network (DMN) and between the DMN and other brain networks. Functional connectivity measures will be compared between adolescents with attention-deficit/hyperactivity disorder and healthy controls.
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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