Betamethasone vs Dextrose Injections in Trigger Finger

NCT07681804 · tracked via the Priya Life Science Turkey tracker

Sponsor

Istanbul University - Cerrahpasa

Phase

Not applicable

Started

2026-06-30

Last updated

2026-07-28

Condition(s) studied

Trigger Finger

Investigational drug(s) / intervention(s)

Betamethasone →Dextrose Injection

Betamethasone: Ultrasound-guided injection of 1 ml lidocaine combined with 1 ml betamethasone administered at the A1 pulley level for the treatment of trigger finger.

Dextrose Injection: Ultrasound-guided injection of 1 ml lidocaine combined with 1 ml 30% dextrose solution resulting in a final concentration of 15% dextrose, administered at the A1 pulley level for the treatment of trigger finger.

Study summary

This study aims to compare the effectiveness of ultrasound-guided betamethasone and dextrose injections in patients with trigger finger.

Trigger finger is a common hand condition characterized by pain, clicking, and locking of the finger due to tendon entrapment at the A1 pulley. Corticosteroid injections are widely used as a first-line treatment; however, they may be associated with potential side effects.

Dextrose injection is an alternative treatment that may promote tissue healing through regenerative mechanisms. However, there is limited high-quality evidence regarding its effectiveness in trigger finger.

In this randomized controlled trial, patients will be assigned to receive either betamethasone or dextrose injection under ultrasound guidance. The primary outcome will be pain intensity measured by the Numeric Rating Scale (NRS). Secondary outcomes will include triggering severity, hand function, grip and pinch strength, and fine motor skills evaluated over a 12-week follow-up period.

The results of this study may help determine whether dextrose injection is a safe and effective alternative to corticosteroid treatment in trigger finger.

Eligibility

Sex

ALL

Min age

18 Years

Max age

75 Years

Healthy volunteers

Inclusion Criteria: * Age between 18 and 75 years * Clinical diagnosis of trigger finger * Presence of symptoms for at least 4 weeks Exclusion Criteria: * Previous surgery on the affected finger * Injection treatment to the affected finger within the previous 3 months * Active local or systemic infection * Active malignancy * Active inflammatory rheumatic disease (e.g., rheumatoid arthritis, ankylosing spondylitis, polymyalgia rheumatica, vasculitis) * Uncontrolled diabetes mellitus and/or uncontrolled hypertension * Autoimmune connective tissue diseases (e.g., systemic lupus erythematosus, antiphospholipid syndrome, systemic sclerosis, Sjögren syndrome, polymyositis, dermatomyositis, adult-onset Still's disease) * Coagulopathy that increases the risk of injection procedures * Pregnancy * Known allergy or hypersensitivity to lidocaine, betamethasone, or dextrose * Mental impairment or severe psychiatric disorder that may interfere with study participation or informed consent

Primary outcome measure(s)

Change in pain intensity assessed by Numeric Rating Scale (NRS) — Baseline, 1 hour, 2 weeks, 4 weeks, and 12 weeks
Pain intensity will be evaluated using the 11-point Numeric Rating Scale (NRS), where 0 indicates no pain and 10 indicates worst imaginable pain.

Trial sites (1)

Facility	City	Region	Status
Istanbul University - Cerrahpasa, Cerrahpasa Faculty of Medicine	Istanbul	Turkey (Türkiye)	Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07681804 on ClinicalTrials.gov ↗ ← All trials in Turkey