Inflammatory Indices, Early Mortality, and ICU Stay in Geriatric PFN Patients

NCT07607886 · tracked via the Priya Life Science Turkey tracker

Sponsor

Saglik Bilimleri Universitesi

Phase

Observational

Started

2021-01-01

Last updated

2026-05-28

Condition(s) studied

Intertrochanteric Femur FractureHip Fracture SurgeriesGeriatric Anesthesia

Study summary

This retrospective observational cohort study aims to evaluate the association between preoperative and postoperative inflammatory indices and early postoperative outcomes in geriatric patients undergoing proximal femoral nailing (PFN) for intertrochanteric femur fractures. The primary outcome of the study is 30-day mortality, while the secondary outcome is intensive care unit (ICU) length of stay. Various inflammatory biomarkers derived from routine laboratory parameters, including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), systemic immune-inflammation index (SII), systemic inflammation response index (SIRI), immune-inflammatory prognostic index (IPI), aggregate index of systemic inflammation (AIS), and RDW-to-albumin ratio (RAR), will be analyzed to investigate their prognostic value in the acute postoperative period. The study seeks to identify simple and readily accessible biomarkers that may contribute to early risk stratification and perioperative management in elderly hip fracture patients.

Eligibility

Sex

ALL

Min age

65 Years

Max age

—

Healthy volunteers

Inclusion Criteria: * Patients aged 65 years and older * Diagnosis of intertrochanteric femur fracture * Undergoing proximal femoral nailing (PFN) surgery * Availability of preoperative laboratory data * Availability of early postoperative laboratory measurements * Availability of 30-day mortality data * Availability of intensive care unit admission and ICU length of stay data * Complete electronic medical records Exclusion Criteria: * Patients with missing clinical or laboratory data * Pathological fractures * Multiple trauma patients * Revision surgeries * Presence of active infection or sepsis before surgery * Hematologic diseases that could affect inflammatory indices * Unavailable 30-day mortality or ICU data

Primary outcome measure(s)

30-Day Mortality — Within 30 days after surgery
Evaluation of all-cause mortality occurring within the first 30 postoperative days in geriatric patients undergoing proximal femoral nailing surgery.

Trial sites (1)

Facility	City	Region	Status
University of Health Sciences Gazi Yaşargil Training and Research Hospital	Diyarbakır	Diyarbakır

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07607886 on ClinicalTrials.gov ↗ ← All trials in Turkey