Serratus Posterior Superior Intercostal Plane Block Versus Intrathecal Morphine in VATS

NCT07540104 · tracked via the Priya Life Science Turkey tracker

Sponsor

Ondokuz Mayıs University

Phase

Not applicable

Started

2026-04-15

Last updated

2026-08-10

Condition(s) studied

Thoracic AnesthesiaPostoperative PainVideo Assisted Thoracic Surgery (VATS)

Investigational drug(s) / intervention(s)

Intrathecal MorphineSerratus Posterior Superior Intercostal Plane Block

Intrathecal Morphine: Preservative-free morphine at 5 µg/kg based on ideal body weight is diluted with 0.9% saline to a total volume of 3 mL and administered intrathecally before induction of general anesthesia.

Serratus Posterior Superior Intercostal Plane Block: Ultrasound-guided serratus posterior superior intercostal plane block is performed before induction of general anesthesia using 30 milliliters of 0.25 percent bupivacaine with epinephrine injected into the interfascial plane between the serratus posterior superior muscle and intercostal muscles.

Study summary

This study aims to compare the analgesic effects of the serratus posterior superior intercostal plane block and intrathecal morphine in patients undergoing video-assisted thoracoscopic surgery.

This is a prospective, randomized, controlled, single-center clinical trial including adult patients undergoing elective thoracoscopic surgery. Participants will be randomly assigned to receive either a serratus posterior superior intercostal plane block or intrathecal morphine before general anesthesia.

The primary outcome is cumulative opioid consumption during the first 24 postoperative hours, expressed as intravenous morphine milligram equivalents. Secondary outcomes include pain scores, time to first analgesic request, quality of recovery, and postoperative complications.

The study aims to determine whether these two techniques differ in their effectiveness for postoperative pain management.

Eligibility

Sex

ALL

Min age

18 Years

Max age

75 Years

Healthy volunteers

Inclusion Criteria: * Age between 18 and 75 years * American Society of Anesthesiologists physical status I to III * Scheduled for elective video-assisted thoracoscopic surgery, including wedge resection, segmentectomy, or lobectomy Exclusion Criteria: * Refusal to participate * Pregnancy * Morbid obesity (body mass index greater than 40 kg per square meter) * Allergy to study medications * Neuropsychiatric disorders, cognitive impairment, or inability to communicate * History of substance abuse * Active systemic infection or infection at the planned injection site * Severe cardiac, respiratory, hepatic, renal, or endocrine disease. * Chronic pain syndrome or ongoing chronic pain treatment * Emergency surgery or previous ipsilateral VATS or thoracotomy * Preoperative opioid use: ≥15 mg oral morphine equivalents/day for ≥30 days within the previous 3 months. * Anticipated need for postoperative mechanical ventilation. * Contraindications to neuraxial or peripheral regional anesthesia, including anticoagulant therapy, coagulopathy, infection, or relevant anatomical abnormalities.

Primary outcome measure(s)

Cumulative IV-MME during the first 24 hours after postoperative admission following extubation — 24 hours
Total opioid consumption during the first 24 postoperative hours is expressed as intravenous morphine milligram equivalents, including patient-controlled analgesia and rescue analgesia.

Trial sites (1)

Facility	City	Region	Status
Ondokuz Mayis University	Atakent	Samsun	Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07540104 on ClinicalTrials.gov ↗ ← All trials in Turkey