Low-Flow Anesthesia Without Wash-in: Effects on Oxygenation and Depth of Anesthesia

Condition(s) studied

Investigational drug(s) / intervention(s)

Initiation of low-flow anesthesia without wash-in following intubation: After endotracheal intubation, fresh gas flow is set to 0.75 L/min with 60% O₂. The sevoflurane vaporizer is initially set to 8%, and the sevoflurane concentration is subsequently titrated according to the target MAC value. Anesthesia depth and oxygenation are monitored using PSI monitoring and serial arterial blood gas measurements.

Study summary

This study aims to evaluate whether adjusting the fresh gas flow rate to low-flow immediately after intubation, without performing a wash-in, is a reliable approach with respect to depth of anesthesia and oxygenation.

Eligibility

Primary outcome measure(s)

• Comparison of arterial oxygen partial pressure (PaO₂) values between groups — Measured at 10, 20, 30, and 45 minutes after induction of anesthesia and before the end of surgery.
  Comparison of arterial oxygen partial pressure (PaO₂) and Patient State Index (PSI) values between groups.
• Comparison of Patient State Index (PSI) values between groups. — Continuously monitored intraoperatively and recorded at 10, 20, 30, and 45 minutes after induction of anesthesia.
  PSI is an EEG-based index ranging from 0 to 100. Lower values indicate deeper anesthesia; the target range is 25-50 during general anesthesia.

Trial sites (1)

More Erzincan Binali Yildirim Universitesi trials in Turkey

Other trials for the same condition