rTMS M1 Motor Cortex Protocol: Repetitive transcranial magnetic stimulation (rTMS) will be applied using the MagVenture MagPro R30 device with a Figure Eight Coil according to the study protocol. rTMS will be delivered to the contralateral primary motor cortex (M1) upper extremity motor area at a low frequency of 1 Hz, 5 sessions per week for 4 weeks, totaling 20 sessions.
Sham rTMS Protocol: Sham (placebo) repetitive transcranial magnetic stimulation (rTMS) will be applied to mimic the procedure without delivering active stimulation. It was planned to apply it daily for 20 sessions.
Study summary
The aim of this study is to investigate the effects of repetitive transcranial magnetic stimulation (rTMS) added to conventional neurological rehabilitation on heart rate variability (HRV), quality of life, upper extremity muscle strength and autonomic symptoms in patients with stroke.
Eligibility
Sex
ALL
Min age
35 Years
Max age
80 Years
Healthy volunteers
No
Inclusion Criteria:
* Participants aged 35-80 years admitted to the Afyonkarahisar Health Sciences University Hospital Physical Medicine and Rehabilitation Unit for neurological rehabilitation after stroke
* Participants with a history of stroke of at least 3 months
* Neurologically and medically stable participants willing to participate regularly in the study
* Participants capable of following commands
Exclusion Criteria:
* Serious cardiac disease, uncontrolled hypertension
* Epilepsy or history of antiepileptic drug use
* Intracranial metallic implants
* Inner ear implants
* Malignancy
* Active infection
* Skin infection or open wound in the intervention area
* Brain lesions or medications that may alter the seizure threshold
* Increased intracranial pressure
* Uncontrolled migraine
* Fracture or surgery on the hemiplegic side within the last 6 months
* Pregnancy
Primary outcome measure(s)
Change from Baseline in Heart Rate Variability (HRV) Assessment at the 4th week — Baseline and after final rTMS session( at 4th week) 24-hour Holter monitoring, also known as ambulatory electrocardiography, records the heart rhythm continuously over a 24-hour period using electrodes placed on the patient's chest during daily activities. A three-channel Holter device collects data from three different leads. Heart rate variability (HRV), reflecting autonomic nervous system function and cardiovascular regulation, is calculated from the Holter recordings. Continuous Electrocardiography (ECG) data are analyzed by precisely calculating R-R intervals and removing ectopic beats. HRV parameters are then computed using specialized software or statistical programs. Recordings will be obtained at baseline and final repetitive transcranial magnetic stimulation (rTMS) sessions, and HRV parameters will be calculated separately.
Trial sites (1)
Facility
City
Region
Status
Afyonkarahisar Health Science University
Afyonkarahisar
Turkey (Türkiye)
Recruiting
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This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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