Methamphetamine Use DisorderMethamphetamine Induced Psychosis
Study summary
This prospective cohort study aims to examine and compare electrocardiogram (ECG) parameters in subjects diagnosed with Methamphetamine Use Disorder (MUD) and Methamphetamine-Induced Psychotic Disorder (MP) during inpatient psychiatric treatment. ECG findings at hospital admission and during remission prior to discharge will be evaluated and compared between groups. The study also aims to determine whether methamphetamine-induced psychosis is associated with greater ECG abnormalities and increased cardiac risk compared to methamphetamine use without psychosis.
Eligibility
Sex
MALE
Min age
18 Years
Max age
65 Years
Healthy volunteers
Accepted
1. For Methamphetamine Use Disorder (MUD) Group:
\*Inclusion Criteria:
* Diagnosis of MUD according to DSM-5-TR
* Medication-free for at least one month prior to admission
* Age ≥ 18 years and \<65 years
* Provided informed consent
For Methamphetamine Use Disorder (MUD) Group:
\*Exclusion Criteria:
• Hypertension
* Diabetes mellitus
* Chronic kidney disease
* Rheumatoid arthritis
* Systemic lupus erythematosus
* Cardiac illness
* Severe neurological disorders
* Immunological or systemic illness
* Primary psychiatric disorders other than MUD
* Alcohol use disorder
2. For Methamphetamine-Induced Psychotic Disorder (MP) Group:
\*Inclusion Criteria:
* Diagnosis of MP according to DSM-5-TR
* Medication-free for at least one month prior to admission
* Age ≥ 18 years and \<65 years
* Provided informed consent
For Methamphetamine-Induced Psychotic Disorder (MP) Group:
\*Exclusion Criteria:
* Hypertension
* Diabetes mellitus
* Chronic kidney disease
* Rheumatoid arthritis
* Systemic lupus erythematosus
* Cardiac illness
* Severe neurological disorders
* Immunological or systemic illness
* Primary psychiatric disorders other than MP
* Alcohol use disorder
3. For Healthy Control Group:
\*Inclusion Criteria:
* No psychiatric diagnosis
* No systemic or immunological illness
* Medication-free for at least one month
* Age ≥ 18 years and \<65 years
* Provided informed consent
For Healthy Control Group:
\*Exclusion Criteria:
• Hypertension
* Diabetes mellitus
* Chronic kidney disease
* Rheumatoid arthritis
* Systemic lupus erythematosus
* Cardiac illness
* Severe neurological disorders
* Immunological or systemic illness
* Primary psychiatric disorders other than schizophrenia
* Alcohol/drug/substance use
Primary outcome measure(s)
Electrocardiogram (ECG) — At baseline and at 6 weeks of hospitalization (for healhty control group only at baseline) The process of recording these electrical currents generated in the heart on paper is called an electrocardiogram (ECG). An ECG consists of waves. These waves are composed of P, Q, R, S, T waves and various intervals (such as the PR interval and QT interval). The P wave occurs during the contraction of the atria, and the QRS wave occurs during the contraction of the ventricles. ECG parameters to be evaluated include: QT interval, QTc interval, QRS duration, Tp-e interval, Tp-e/QTc ratio, ST depression, P-wave dispersion, QT dispersion, fragmented QRS.
Trial sites (1)
Facility
City
Region
Status
Elazığ Mental Health and Diseases Hospital
Elâzığ
Elâzığ
Recruiting
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This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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