NIRS and BIS Monitoring During Cerebral Aneurysm Coiling

Condition(s) studied

Investigational drug(s) / intervention(s)

Near-Infrared Spectroscopy (NIRS) and Bispectral Index (BIS) Monitoring: Near-infrared spectroscopy (NIRS) and bispectral index (BIS) monitoring are performed as part of routine intraoperative anesthesia monitoring during endovascular coil embolization for cerebral aneurysm. No additional intervention beyond standard clinical care is applied; data are recorded observationally.

Study summary

This prospective observational study aims to evaluate the effectiveness of Near-Infrared Spectroscopy (NIRS) and Bispectral Index (BIS) monitoring during endovascular coil embolization of cerebral aneurysms under general anesthesia. Changes in regional cerebral oxygen saturation (rSO₂) measured by NIRS will be assessed in relation to BIS values and hemodynamic parameters throughout the procedure.

The frequency, duration, and severity of cerebral desaturation episodes detected by NIRS, as well as their association with anesthetic depth and hemodynamic fluctuations, will be analyzed. The study does not involve any additional intervention beyond routine clinical monitoring.

Eligibility

Primary outcome measure(s)

• Correlation between intraoperative cerebral desaturation and intraoperative hemodynamic parameters — During the intraoperative period
  Correlation between intraoperative cerebral desaturation episodes (defined as a ≥20% decrease from baseline regional cerebral oxygen saturation \[rSO₂\], measured as percentage (%) using Near-Infrared Spectroscopy \[NIRS\]) and the following intraoperative parameters: * Mean arterial pressure (mmHg), measured via invasive arterial catheter * Heart rate (beats per minute, bpm), measured using electrocardiography (ECG) * Peripheral oxygen saturation (SpO₂, %), measured via pulse oximetry * End-tidal carbon dioxide (EtCO₂, mmHg), measured using capnography * Bispectral Index (BIS, unitless scale 0-100), measured using a BIS monitor Correlation will be analyzed using Pearson or Spearman correlation coefficients, as appropriate.

Trial sites (1)

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