Single-step vs Stepwise Lung Recruitment Maneuvers After Cardiopulmonary Bypass

Condition(s) studied

Investigational drug(s) / intervention(s)

Single Step Lung Recruitment Maneuver: A sustained inflation lung recruitment maneuver with an airway pressure of 30 cmH₂O applied for 30 seconds after separation from cardiopulmonary bypass, combined with 8 cmH₂O positive end-expiratory pressure.

Stepwise Lung Recruitment Maneuver: A stepwise lung recruitment maneuver in which airway pressure is increased by 5 cmH₂O every 5 seconds up to 30 cmH₂O and then decreased in the same manner after separation from cardiopulmonary bypass, combined with 8 cmH₂O positive end-expiratory pressure.

Study summary

This prospective randomized controlled trial aims to compare the hemodynamic and pulmonary effects of single-step and stepwise lung recruitment maneuvers in adult patients undergoing elective cardiac surgery with cardiopulmonary bypass. After separation from cardiopulmonary bypass, patients will be randomized to receive either a single-step sustained inflation recruitment maneuver or a stepwise incremental recruitment maneuver, both combined with 8 cmH₂O positive end-expiratory pressure. The primary outcome is the change in cardiac index before and after the recruitment maneuver. Secondary outcomes include lung ultrasound atelectasis score, and hemodynamic parameters.

Eligibility

Primary outcome measure(s)

• Change in Cardiac Index — Intraoperative period
  Difference in cardiac index measured before and after the lung recruitment maneuver.

Trial sites (1)

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