Post-induction Hypotension (PIH)Geriatric PatientOncologic DiseaseHemodynamic Effects of General AnesthesiaRisk Factors Associated With Anesthesia-Induced Hypotension
Study summary
This observational clinical study aims to investigate the incidence and risk factors of post-induction hypotension (PIH) in geriatric cancer patients undergoing surgery under general anesthesia. PIH is defined as a drop in mean arterial pressure of ≥30% from baseline or below 65 mmHg within the first 20 minutes after anesthesia induction, prior to surgical stimulation.
The primary objective is to determine the frequency of PIH in elderly oncology patients. Secondary objectives include evaluating the association of PIH with age, ASA score, cancer type, oncological treatments (chemotherapy/radiotherapy), comorbidities, medication use, anemia, biochemical parameters, and preoperative perfusion index (PI) and pleth variability index (PVI).
Findings from this study are expected to contribute to improved perioperative management and to the development of tailored anesthesia protocols for geriatric oncology patients.
Eligibility
Sex
ALL
Min age
65 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria:
* Adults ≥65 years of age
Patients with a diagnosis of cancer and scheduled for surgery
Ability and willingness to provide written informed consent
ASA physical status class II-IV
Exclusion Criteria:
Patients under 65 years of age
Patients without a confirmed oncologic diagnosis
Refusal to provide written informed consent
Patients undergoing regional anesthesia
Patients with tracheostomy or requiring multiple intubation attempts
History of peripheral arterial disease
Use of vasopressors before the start of surgery
Uncontrolled hypertension (blood pressure \>180/110 mmHg)
Advanced heart failure (Ejection Fraction \<40%)
Severe arrhythmias such as atrial fibrillation or significant ventricular arrhythmias that preclude reliable hemodynamic monitoring
Primary outcome measure(s)
Incidence of Post-Induction Hypotension (PIH) in Geriatric Oncologic Patients — From anesthesia induction to 15 minutes after intubation (≈ first 20 minutes post-induction) PIH defined as ≥30% decrease from pre-induction MAP or MAP \< 65 mmHg at any measurement within the window (NIBP every 2 minutes). Outcome reported as the proportion of participants meeting PIH criteria.
Trial sites (1)
Facility
City
Region
Status
Dr. Abdurrahman Yurtaslan Oncology Training and Research Hospital
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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