Routine anesthesia care (desflurane at different low-flow rates: 0.5, 1.0, 1.5 L/min); no intervention assigned as part of the study.
Routine anesthesia care (desflurane at different low-flow rates: 0.5, 1.0, 1.5 L/min); no intervention assigned as part of the study.: Routine anesthesia care (desflurane at different low-flow rates: 0.5, 1.0, 1.5 L/min); no intervention assigned as part of the study.
Study summary
This study investigates the effects of low-flow desflurane anesthesia in adult patients undergoing major abdominal surgery. The researchers will examine whether different low-flow strategies:
Cause differences in the Bispectral Index (BIS), which measures brain activity during anesthesia, Affect postoperative cognitive functions such as memory and attention.
Participants will:
Receive desflurane anesthesia during surgery, Have anesthesia delivered at different low-flow rates, Have their BIS values monitored throughout the operation, Complete tests after surgery to evaluate their cognitive functions.
This research will help determine the safety of different low-flow strategies and their impact on patients' cognitive recovery after surgery.
Eligibility
Sex
ALL
Min age
18 Years
Max age
75 Years
Healthy volunteers
No
Inclusion Criteria:
Patients aged 18-75 years
ASA physical status I-III
Scheduled for elective major abdominal surgery
Provided written informed consent
Normal preoperative neurocognitive function
Exclusion Criteria:
History of neurological or psychiatric disorders
History of cognitive impairment
Diagnosed hepatic or renal insufficiency
Presence of other systemic diseases contraindicating anesthesia
Primary outcome measure(s)
Change from Baseline in Mini-Mental State Examination (MMSE) Score Postoperatively — From baseline (preoperative assessment, within 24 hours before surgery) to postoperative assessments at 24 hours and 7 days after surgery Measure: Change in cognitive function assessed by the Mini-Mental State Examination (MMSE)
Time Frame: From baseline (preoperative assessment) to postoperative assessment (within 24 hours after surgery)
Description: The MMSE will be used to evaluate changes in cognitive function in patients receiving desflurane anesthesia at different low-flow rates. The primary endpoint is the difference between preoperative and postoperative MMSE scores.
Trial sites (1)
Facility
City
Region
Status
Dr. Abdurrahman Yurtaslan Oncology Training and Research Hospital
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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