The Effect of Two Different Oral Care Solutions on Ventilator-Associated Pneumonia and Oral Health of Mechanically Ventilated Patients in the Intensive Care Unit
control group(chlorhexidine): The sponge swab is dipped in 0.25% chlorhexidine solution and used once for each part of the mouth, 4 times a day to provide oral care.
Experimental Group(cetylpyridinium chloride): The mouth is cleaned by dipping a sponge swab into 0.05% cetylpyridinium chloride solution and using it once for each part of the mouth, 4 times a day.
Study summary
The aim of this observational study is to evaluate the effects of two different oral care solutions on ventilator-associated pneumonia and oral health in mechanically ventilated participants in the intensive care unit.
Did oral health improve in participants who used cetylpyridinium chloride? Did pneumonia develop? Did oral health improve in participants who used chlorhexidine chloride? Did pneumonia develop? The results will be evaluated by giving oral care to the participants with these solutions for 5 days with the same protocol.
Eligibility
Sex
ALL
Min age
18 Years
Max age
90 Years
Healthy volunteers
No
Inclusion Criteria:• Being 18 years of age or older
* Requiring mechanical ventilation for at least 48 hours
* Not having a diagnosis of aspiration pneumonia
* Having a Clinical Lung Infection Score (CPIS) \<6 on the first day
* Not having a diagnosis of pneumonia or COVID
* Not having facial or oral trauma
* Being within the first 24 hours of the intubation process
* Not having a medical impediment to elevating the head of the bed 30o
Exclusion Criteria:
* Not accepting to participate in the study
* Termination of MV support for less than 48 hours
* Being allergic to any of the solutions to be used in oral care
* Being diagnosed with immunodeficiency
* Having thrombocytopenia, leukopenia and oral aphthae, stomatitis, candidiasis, gingivitis
* Using immunosuppressive drugs
Primary outcome measure(s)
EFFECTS OF TWO DIFFERENT ORAL CARE SOLUTIONS ON VENTILATOR-ASSOCIATED PNEUMONIA AND ORAL HEALTH OF PATIENTS CONNECTED TO MECHANICAL VENTILATORS IN THE INTENSIVE CARE UNIT — from registration until the end of the 5th day The same person evaluates the patients' mouths every day at 07:00 with the oral hygiene oral assessment scale.
On the 1st, 3rd and 5th days, patients are evaluated with the clinical pulmonary infection score. After all these evaluations, the patient is diagnosed with pneumonia or not by the intensive care specialist.
Trial sites (1)
Facility
City
Region
Status
Gulhane Training and Research Hospital
Ankara
Turkey (Türkiye)
More Saglik Bilimleri Universitesi trials in Turkey
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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