HIPEC Surgery and Hemodynamics

Condition(s) studied

Study summary

Hyperthermic Intraperitoneal Chemotherapy (HIPEC) involves the intraoperative administration of heated chemotherapeutic agents into the abdominal cavity following cytoreductive surgery (CRS). The increasing use of CRS combined with HIPEC has introduced certain procedural and physiological considerations that distinguish it from other surgical interventions, posing unique challenges for researchers and clinicians alike.

Despite advancements in surgical and anesthetic techniques, this combined approach is frequently associated with significant hemodynamic instability, coagulation abnormalities, respiratory complications, and nutritional imbalances.

The study aims to contribute to the existing body of knowledge by examining the physiological alterations induced by HIPEC, thereby offering practical insights and guidance for investigators involved in the management and study of this complex therapeutic modality.

Eligibility

Primary outcome measure(s)

• physiological parameter ; heart rate — Intraoperatively
  HIPEC is usually the application of chemotherapy that lasts between 45 and 90 minutes after the end of cytoreductive surgery. During HIPEC application (45-90 minutes), Heart rate: will be recorded every 10 minutes as beats / minute.
• physiological parameter; systolic/diastolic blood pressure — Intraoperatively
  Systolic/diastolic blood pressure will be recorded in mmHg every 10 minutes.
• physiological parameter; SpO2 — Intraoperatively
  SpO2 will be recorded as percent every 10 minutes.
• anesthesia device measurement parameter; EtCo2 — Intraoperatively
  EtCo2 will be recorded every 10 minutes as mmHg.
• anesthesia device measurement parameter; Pmax — Intraoperatively
  Pmax will be recorded as cmH2O every 10 minutes.

Trial sites (1)

Other trials for the same condition