Opioid-Free Anesthesia (OFA): Opioid-free anesthesia using a multimodal approach, including dexmedetomidine, lidocaine, ketamine, and magnesium sulfate. No intraoperative opioids are administered.
Opioid-Based Intravenous Anesthesia (OBA-IV): Standard opioid-based intravenous anesthesia using propofol, remifentanil, and neuromuscular blockade.
Opioid-Based Inhalational Anesthesia (OBA-Inh): Standard opioid-based inhalational anesthesia using sevoflurane, remifentanil, and neuromuscular blockade.
Study summary
This study will evaluate how different anesthesia techniques affect inflammation after bariatric surgery. Patients will be randomly assigned to receive one of three approaches: opioid-free anesthesia, intravenous anesthesia with opioids, or inhalational anesthesia with opioids.
The study will measure blood levels of inflammation-related substances (such as IL-6, CRP, cortisol, ESR , WBC and lactate) at several time points before and after surgery. Heart rate variability will also be monitored as an indicator of the body's stress response.
The results may help identify anesthesia strategies that reduce inflammation and improve recovery in patients undergoing bariatric surgery.
Eligibility
Sex
ALL
Min age
18 Years
Max age
65 Years
Healthy volunteers
No
Inclusion Criteria:
* Patients scheduled for bariatric surgery.
* Age 18-65 years.
* BMI ≥ 30 kg/m².
* ASA physical status II-III.
Exclusion Criteria:
* Pregnancy or breastfeeding.
* Chronic opioid use before surgery.
* Severe renal or hepatic failure.
* Uncontrolled psychiatric disorders.
* Significant intraoperative complications requiring protocol deviation.
Primary outcome measure(s)
Serum IL-6 Level — Preoperative (baseline), immediately after surgery, and 24 hours post-surgery. Measurement of interleukin-6 (IL-6) concentration in pg/mL to evaluate inflammatory response.
C-reactive Protein (CRP) Level — Preoperative (baseline), immediately after surgery, and 24 hours post-surgery. Measurement in mg/L to assess systemic inflammation.
Serum Cortisol Level — Preoperative (baseline), immediately after surgery, and 24 hours post-surgery. Measurement in μg/dL.
Heart Rate Variability (HRV) as an Inflammatory Marker — Collected continuosly from the induction of the anesthesia until the end of surgery Heart Rate Variability (HRV) as an Inflammatory Marker and its correlation with blood levels of inflammatory markers Heart Rate Variability (HRV) as an Indicator of Inflammatory Response
Serum Lactate Level — Preoperative (baseline), immediately after surgery, and 24 hours post-surgery. Measurement in mmol/L as a marker of metabolic response.
Erythrocyte Sedimentation Rate (ESR) — Preoperative (baseline), immediately after surgery, and 24 hours post-surgery. Measurement of ESR in mm/h to assess systemic inflammation.
Differential White blood Cell count (WBC). — Preoperative (baseline), immediately after surgery, and 24 hours post-surgery. Measurement of total white blood cell count in peripheral blood, expressed in thousands of cells per microliter (10³/μL). Assessment of the percentage distribution of white blood cell subtypes, including neutrophils, lymphocytes, monocytes, eosinophils, and basophils, expressed as a percentage of total leukocytes.
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
We use cookies to analyse site traffic and improve your experience. With your consent, we may also use cookies for advertising. You can change your choice at any time.