Impact of Antioxidant-rich Supplementation on Skin Carotenoids Status, Antioxidant Status and Cardiometabolic Health in Overweight and Obese Individuals

NCT07748468 · tracked via the Priya Life Science Singapore tracker

Sponsor

National University of Singapore

Phase

Not applicable

Started

2026-08-15

Last updated

2026-08-05

Condition(s) studied

Overweight , ObesityAntioxidant Status

Investigational drug(s) / intervention(s)

Antioxidant-rich supplementation ElementAntioxidant-rich supplementation Optimal

Antioxidant-rich supplementation Element: Maintained habitual diet with additionally taking LifePak Element for 12 weeks

Antioxidant-rich supplementation Optimal: Maintaining habitual diet with additionally taking LifePak Optimal for 12 weeks

Study summary

This study aims to evaluate the effects of antioxidant-rich supplementation on skin carotenoid status, antioxidant status, and cardiometabolic health in overweight and obese individuals. The study may provide additional scientific evidence to support the further refinement of current dietary and nutritional recommendations.

Eligibility

Sex

ALL

Min age

21 Years

Max age

70 Years

Healthy volunteers

Accepted

Inclusion Criteria: * Able to give informed consent (AMT score ≥ 8 for older adults \[65-70 years old\]) * Adults 21-70 years old * English-literate * Have venous access sufficient to allow for blood sampling as per the protocol * No drastic change of diet for the past 1 year * If taking medication, has been consistently taking antihypertensive/cholesterol-lowering/type-2 diabetic medication for more than 3 years prior to starting the study Exclusion Criteria: * Weight change \> 3kg in the past 3 months * Exercising vigorously over the past 3 months * Taking medications or dietary supplements which may impact eye/skin health * Taking lipid-lowering and blood pressure controlling medications less than 3 years * Smoking * Drinking more than 2 alcoholic drinks per day * Pregnant, lactating, or planning pregnancy in the next 6 months

Primary outcome measure(s)

Change in Skin Carotenoid Score Measured by Prysm iO™ from Baseline to Week 12 — Week 0, 4, 8, 12
Skin carotenoid status will be assessed using the Prysm iO™ device. The device scans the participant's fingertip and provides a skin carotenoid score, also referred to as the Prysm Score. Results will be reported as the numerical Prysm Score. Higher scores indicate higher skin carotenoid levels.
Mean Change from Baseline in Blood Carotenoid Concentration — Week 0 and Week 12
Blood carotenoid concentration will be assessed using blood samples collected from participants. Results will be reported as the mean change from baseline in blood carotenoid concentration at Week 12. Higher concentrations indicate higher circulating carotenoid status.

Trial sites (1)

Facility	City	Region	Status
NUS, Department of Food Science and Technology, 1 Science Drive 3, Block S13, #03-07, Singapore, 117550	Singapore	Singapore

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07748468 on ClinicalTrials.gov ↗ ← All trials in Singapore