Dietary protein: Intervention of the study include consuming a higher protein diet. Depending on the group allocation, this is done by asking the subjects to follow "My Healthy Plate" diet and consumption of 20g of protein isolates (casein or soy).
Study summary
Today, insufficient sleep has become a growing global problem. Sleep is essential to health and changes in sleep patterns are a part of the aging process. Inadequate and low-quality sleep also increases the risk for age-related cognitive decline and disease conditions. More importantly, due to COVID-19 health emergency, there is a significant increase of psychological distress and symptoms of mental illness and a worsening of quality of sleep. Therefore, there is an urgent need to investigate the way of improving sleep quality, in particular during and post COVID-19 period, in older adults.
One of the possible strategies in improving sleep quality with lifestyle modification is having higher-protein diet. However, this effect has not been fully elucidated in older adults. In addition, the effect of type of dietary protein on sleep quality is inconclusive and there is no clinical trial which assessed the differential response in sleep quality between animal-sourced protein vs. plant-sourced protein. Therefore, the purpose of this research project is to assess the impact of different types of higher dietary protein intake on sleep quality in Singapore older adults.
Findings from the proposed research will provide the scientific evidence of the beneficial effects of regularly consuming higher-protein diet on sleep quality in Singapore older adults. In addition, this research may validate the differential effect of different type of dietary protein on sleep quality. The results from the proposed research will also assist a practical guidance of nutritional behaviour changes providing sleep promoting effects to a large proportion of the Singapore population.
Eligibility
Sex
ALL
Min age
60 Years
Max age
85 Years
Healthy volunteers
Accepted
Inclusion Criteria:
1. Adults 60-85 years old
2. Not following HPB diet
Exclusion Criteria:
1. Weight change \> 3kg in the past 3 months
2. Exercise vigorously over the past 3 months
3. Drinking more than 2 alcoholic drinks per day
4. (if applicable) Pre-menopausal women
5. Taking dietary supplements or medications which may impact sleep outcomes (e.g. Nutritional Shakes (e.g. Ensure), Trp, 5-HTP or melatonin supplementations) the past 1 month
6. Taking dietary supplements which may impact the gut microbiota (e.g. antibiotics, prebiotics, probiotics) the past 2 months (a list of fermented foods)
7. Impaired renal function (normal values: estimated glomerular filtration rate ≥ 90 mL/min/1.73 m2 calculated by chronic kidney disease epidemiology collaboration equation; CKD EPI)
8. Soy intolerance and/or allergy or any medical conditions that may be affected by consumption of soy products (e.g. gout)
9. Prescribed and taking antihypertensive/cholesterol-lowering/ type-2 diabetic medication or Chinese medicine herb which started less than 3 years prior to the intervention participation
10. Diagnosed with gut/gastrointestinal issues such as lactose intolerance and irritable bowel syndrome (IBS)
Primary outcome measure(s)
Change in sleep quality assessed by validated sleep questionnaires — Every 4 weeks (week 0, week 4, week 8, week 12 and week 16) Pittsburgh Sleep Quality Index Questionnaire (PSQI) will be used to assess the sleep quality. Overall score ranging from 0 to 21 points, where lower scores denote a healthier sleep quality.
Change in sleep quality assessed by electronic equipment — Every 4 weeks (week 0, week 4, week 8, week 12 and week 16) An electronic equipment, actigraphy, will be used to assess the sleep quality, including sleep timing and wake up timing.
Change in blood amino acid concentration — Every 8 weeks (week 0 , week 8 and week 16) Amino acid concentration in the blood will be measured
Change in blood serotonin concentration — Every 8 weeks (week 0 , week 8 and week 16) Serotonin concentration in the blood will be measured
Change in urinary 6-sulfatoxymelatonin (aMT6s) concentration — Every 8 weeks (week 0 , week 8 and week 16) 6-sulfatoxymelatonin (aMT6s) concentration in the urine samples will be measured
Trial sites (1)
Facility
City
Region
Status
National University of Singapore
Singapore
Singapore
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This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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