Assessment of Eye Movements in Stroke Patients and Closed-loop Intervention

Condition(s) studied

Investigational drug(s) / intervention(s)

Visual exploration training: Visual exploration of natural scenes guided by closed-loop auditory biofeedback through eye-tracking

Standard neuropsychological rehabilitation: Standard rehabilitation delivered at the IRCCS San Camillo hospital

Study summary

The current study evaluates first the assumption that eye-movements during free viewing behavior are potential biomarkers of visuospatial deficits in stroke population. Second, it assesses the feasibility of a novel visual exploration training to ameliorate visuospatial deficits, by exploiting an auditory biofeedback system coupled with online parsed fixations.

Eligibility

Primary outcome measure(s)

• Change pre-post rehabilitation in eye movements patterns during free viewing — At day 0 and day 30 (i.e., end of the rehabilitation)
  Eye movements patterns described by fixations, saccades and blinks related features summarized by principal component analysis (PCA)
• Change pre-post rehabilitation in Behavioral Inattention Test score — At day 0 and day 30 (i.e., end of the rehabilitation)
  Neuropsychological test assessing visuospatial deficits
• Change pre-post rehabilitation in Trail Making Test score — At day 0 and day 30 (i.e., end of the rehabilitation)
  Neuropsychological test assessing visuospatial abilities, scored as the time to complete the task
• Change pre-post rehabilitation in Posner Test reaction times — At day 0 and day 30 (i.e., end of the rehabilitation)
  Neuropsychological test assessing visuospatial abilities, scored with the measured reaction times
• Change pre-post rehabilitation in Attention Matrices Test — At day 0 and day 30 (i.e., end of the rehabilitation)
  Neuropsychological test assessing visuospatial deficits
• Change pre-post rehabilitation in Brief Visuospatial Memory Test Revised — At day 0 and day 30 (i.e., end of the rehabilitation)
  Neuropsychological test assessing visuospatial memory
• Change pre-post rehabilitation in Bells Test — At day 0 and day 30 (i.e., end of the rehabilitation)
  Neuropsychological test assessing visuospatial deficits
• Change pre-post rehabilitation in Apple Test score — At day 0 and day 30 (i.e., end of the rehabilitation)
  Neuropsychological test assessing visuospatial deficits
• Change pre-post rehabilitation in Comb and Razor Test — At day 0 and day 30 (i.e., end of the rehabilitation)
  Neuropsychological test assessing functional activities to investigate spatial attention deficits
• Change pre-post rehabilitation in Mental Number Interval Bisection — At day 0 and day 30 (i.e., end of the rehabilitation)
  Neuropsychological test investigating spatial biases in the mental number line
• Change pre-post rehabilitation in Anosognosia — At day 0 and day 30 (i.e., end of the rehabilitation)
  Neuropsychological test investigating deficits awareness
• Change pre-post rehabilitation in Load Test — At day 0 and day 30 (i.e., end of the rehabilitation)
  Neuropsychological test assessing spatial attentional deficits with cognitive load as a moderator
• Change pre-post rehabilitation in the Catherine-Bergego Scale score — At day 0 and day 30 (i.e., end of the rehabilitation)
  Test assessing activities of daily living involving spatial attention

Trial sites (2)

More IRCCS San Camillo, Venezia, Italy trials in Italy

Other trials for the same condition