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Clinical trial register · Ireland

Studies with an Irish investigative site

Every study on the ClinicalTrials.gov registry that lists a site in Ireland and is open, about to open, active-but-closed, or enrolling by invitation. Filter it, cite it, and take it away as a file.

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Source: ClinicalTrials.gov, U.S. National Library of Medicine. Complete coverage — all 615 matching records held by the registry are in this view. Synced 23 Sep 2026, 03:15 UTC
615
Studies in scope
all four open statuses
321
Recruiting now
open to new participants
180
Lead sponsors
across recruiting studies
37
Irish site locations
across all listed studies
Phase mix of the 321 recruiting studies
Phase 3 96 Not applicable 79 Observational 76 Phase 2 30 Phase 1/2 20 Other 20
Narrow the register
Matches title, registry number, sponsor, intervention and condition.
Recruitment status
Phase
Lead sponsor
Merck Sharp & Dohme LLC 36 Royal College of Surgeons, Ireland 29 University College Dublin 21 AbbVie 20 University College Cork 19
Site location
Dublin 483 Cork 170 Galway 124 Limerick 56 Waterford 51
All 37 locations
Target enrolment
to
615 of 615 studies
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Status
Study
Lead sponsor
Phase
Enrol
Irish sites
Start
Recruiting
Neoadjuvant and Adjuvant Treatment in Resectable Non-small Cell Lung Cancer
NCT05061550 Non-small Cell Lung Cancer
AstraZeneca
Phase 2
630
Dublin, Galway
2022-04-14
Recruiting
Brentuximab Vedotin in Early Stage Hodgkin Lymphoma
NCT04685616 Hodgkin Lymphoma
University College, London
Phase 3
1,042
Dublin, Galway
2022-04-14
Active, closed
Isa-RVD Study in Patients With Newly Diagnosed Multiple Myeloma
NCT05123131 Multiple Myeloma
Cancer Trials Ireland
Phase 2
54
Dublin, Waterford
2022-04-01
Recruiting
Phase 2/3 Adaptive Study of VX-147 in Adult and Pediatric Participants With APOL1-Mediated Proteinuric Kidney Disease
NCT05312879 Proteinuric Kidney Disease
Vertex Pharmaceuticals Incorporated
Phase 2/3
466
2022-03-30
Active, closed
Pembrolizumab/Vibostolimab (MK-7684A) or Atezolizumab in Combination With Chemotherapy in First Line Treatment of Extensive-Stage Small Cell Lung Cancer (MK-7684A-008/KEYVIBE-008)
NCT05224141 Small Cell Lung Carcinoma
Merck Sharp & Dohme LLC
Phase 3
460
Dublin
2022-03-24
Active, closed
A Study of Belzutifan (MK-6482) Plus Pembrolizumab (MK-3475) Versus Placebo Plus Pembrolizumab in Participants With Clear Cell Renal Cell Carcinoma Post Nephrectomy (MK-6482-022)
NCT05239728 Carcinoma, Renal Cell
Merck Sharp & Dohme LLC
Phase 3
1,800
Dublin, Cork
2022-03-15
Active, closed
A Study of Zanubrutinib Plus Anti-CD20 Versus Lenalidomide Plus Rituximab in Participants With Relapsed/Refractory Follicular or Marginal Zone Lymphoma
NCT05100862 Relapsed/Refractory Follicular Lymphoma, Marginal Zone Lymphoma
BeOne Medicines
Phase 3
799
Dublin, Waterford
2022-03-10
Active, closed
A Phase 3 Study to Examine the Efficacy and Safety of ZX008 in Subjects With CDKL5 Deficiency Disorder.
NCT05064878 CDKL5 Deficiency Disorder, Generalized Tonic Clonic Seizure, Epileptic Spasm, Refractory Seizures
Zogenix, Inc.
Phase 3
87
Dublin
2022-03-08
Recruiting
Follow-up Study to Monitor the Efficacy and Safety of the Occlutech® mVSD Cases
NCT05329350 Muscular Ventricular Septal Defect
Occlutech International AB
Observational
50
Dublin
2022-03-03
Recruiting
Characterization of the Blood-Brain Barrier in High-Grade Glioma Through Immunohistochemical, Transcriptional, Fluorescein and Radiological Analyses
NCT07731555 Glioblastoma
Patrick Morris
Not applicable
100
Beaumont
2022-03-01
Active, closed
Direct Measurement of Microstructure of Ingestive Behaviour After Initiation of GLP-1 Receptor Agonist Treatment at Maximum Dose (DIGRAT)
NCT07457424 Metabolic Disease, Obesity & Overweight
University College Dublin
Observational
140
Dublin
2022-02-17
Recruiting
Awareness Detection and Communication in Disorders of Consciousness
NCT03827187 Disorder of Consciousness, Paralysis, Motor Neuron Disease, Stroke
University of Ulster
Not applicable
30
Dublin
2022-02-08
Active, closed
Study of Pembrolizumab (MK-3475) Versus Chemotherapy in Mismatch Repair Deficient (dMMR) Advanced or Recurrent Endometrial Carcinoma (MK-3475-C93/KEYNOTE-C93/GOG-3064/ENGOT-en15)
NCT05173987 Endometrial Neoplasms
Merck Sharp & Dohme LLC
Phase 3
280
Cork, Dublin
2022-02-03
Active, closed
Study Assessing Long-term Safety and Efficacy of Alpelisib in Patients With PIK3CA-Related Overgrowth Spectrum (PROS) Who Previously Participated in Study CBYL719F12002 (EPIK-P1)
NCT04980833 PIK3CA-related Overgrowth Spectrum (PROS)
Novartis Pharmaceuticals
Phase 2
41
Dublin
2022-01-27
Recruiting
Study of STK-012 Alone and With Other Treatments in Patients With Advanced Lung Cancer and Other Cancers
NCT05098132 Advanced Solid Tumor, Non Small Cell Lung Cancer, Untreated Advanced NSCLC, 1st Line NSCLC
Synthekine
Phase 1/2
364
Dublin, Galway
2022-01-25
Active, closed
Post Marketing Clinical Follow Up of the BioProtect Balloon Implant System
NCT05354440 Prostate Cancer
BioProtect
Observational
80
Dublin
2022-01-01
Active, closed
Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia. A Study of Potential Disease Modifying Treatments in Individuals With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation (DIAN-TU)
NCT05269394 Alzheimers Disease, Dementia, Alzheimers Disease, Familial
Washington University School of Medicine
Phase 2/3
197
Dublin
2021-12-22
Active, closed
Effectiveness of the SpaceOAR Vue System in Subjects With Prostate Cancer
NCT04905069 Prostate Cancer
Boston Scientific Corporation
Not applicable
500
Cork
2021-12-21
Active, closed
Study to Assess the Efficacy and Safety of Alpelisib Plus Fulvestrant in Participants With HR-positive (HR+), HER2-negative, Advanced Breast Cancer After Treatment With a CDK4/6 Inhibitor and an Aromatase Inhibitor.
NCT05038735 Breast Cancer
Novartis Pharmaceuticals
Phase 3
210
Dublin
2021-12-17
Active, closed
Efficacy and Safety of Remibrutinib Compared to Teriflunomide in Participants With Relapsing Multiple Sclerosis (RMS) (REMODEL-1)
NCT05147220 Relapsing Multiple Sclerosis
Novartis Pharmaceuticals
Phase 3
1,000
Dublin
2021-12-16
Active, closed
Study Assessing the Long-term Effect of Dupilumab on Prevention of Lung Function Decline in Adult Patients With Uncontrolled Moderate to Severe Asthma
NCT05097287 Asthma
Sanofi
Phase 4
1,339
Cork, Dublin
2021-12-16
Active, closed
Pembrolizumab/Placebo Plus Paclitaxel With or Without Bevacizumab for Platinum-resistant Recurrent Ovarian Cancer (MK-3475-B96/KEYNOTE-B96/ENGOT-ov65).
NCT05116189 Ovarian Cancer, Carcinoma, Ovarian Epithelial, Fallopian Tube Neoplasms
Merck Sharp & Dohme LLC
Phase 3
643
Dublin
2021-12-13
Active, closed
CPD-DARA in Patients With Relapsed/Refractory Multiple Myeloma.
NCT04667663 Multiple Myeloma
Cancer Trials Ireland
Phase 1
16
Cork, Dublin, Galway
2021-12-08
Active, closed
A Study of Zanidatamab in Combination With Chemotherapy Plus or Minus Tislelizumab in Patients With HER2-positive Advanced or Metastatic Gastric and Esophageal Cancers
NCT05152147 Gastric Neoplasms, Gastroesophageal Adenocarcinoma, Esophageal Adenocarcinoma
Jazz Pharmaceuticals
Phase 3
920
Dublin
2021-12-02
Recruiting
(HARBOR) Study to Evaluate Efficacy and Safety of BLU-263 Versus Placebo in Patients With Indolent Systemic Mastocytosis
NCT04910685 Indolent Systemic Mastocytosis, Smoldering Systemic Mastocytosis
Blueprint Medicines Corporation
Phase 2/3
534
Cork
2021-11-30
Active, closed
A Phase 3 Study to Evaluate the Safety and Efficacy of Efgartigimod PH20 Subcutaneous in Adult Patients With Primary Immune Thrombocytopenia
NCT04812925 Primary Immune Thrombocytopenia
argenx
Phase 3
173
Dublin
2021-11-17
Recruiting
The PIONEER-IV Study is Comparing Clinical Outcomes Between Angiography-derived Physiology Guidance to Usual Care in an All-comers PCI Population With Unrestrictive Use of the HT Supreme Sirolimus-eluting Stent
NCT04923191 Coronary Artery Disease
National University of Ireland, Galway, Ireland
Not applicable
2,540
Galway
2021-11-12
Recruiting
Perivenous Dexamethasone Therapy: Examining Reduction of Inflammation After Thrombus Removal to Yield Benefit in Acute Femoropopliteal DVT
NCT04862468 Thrombosis, Deep Vein, Iliofemoral; Thrombosis
Mercator MedSystems, Inc.
Phase 2
80
Galway
2021-10-29
Active, closed
Open-Label Safety Study of Acoramidis (AG10) in Symptomatic ATTR Participants
NCT04988386 Amyloid Cardiomyopathy, Transthyretin-Related
Eidos Therapeutics, a BridgeBio company
Phase 3
389
Dublin
2021-10-27
Active, closed
Australasian Resuscitation In Sepsis Evaluation: FLUid or Vasopressors In Emergency Department Sepsis
NCT04569942 Shock, Septic
Australian and New Zealand Intensive Care Research Centre
Phase 3
1,000
Elm Park
2021-10-26
Active, closed
SPYRAL AFFIRM Global Study of RDN With the Symplicity Spyral RDN System in Subjects With Uncontrolled HTN
NCT05198674 Hypertension, Vascular Diseases, Cardiovascular Diseases, Chronic Kidney Diseases
Medtronic Vascular
Not applicable
1,899
Dublin
2021-10-20
Active, closed
A Study Evaluating the Efficacy and Safety of Afimetoran Compared With Placebo in Participants With Active Systemic Lupus Erythematosus (SLE)
NCT04895696 Systemic Lupus Erythematosus
Beeline Medicines Corporation
Phase 2
248
Dublin, Galway, Manorhamilton
2021-10-11
Recruiting
Precision Diagnosis and Care for Families With Pulmonary Fibrosis in Ireland
NCT06702228 Connective Tissue Diseases, Interstitial Lung Disease, Idiopathic Pulmonary Fibrosis, Familial Idiopathic Pulmonary Fibrosis
Royal College of Surgeons, Ireland
Observational
300
Dublin
2021-09-28
Active, closed
Study of INBRX-109 in Conventional Chondrosarcoma
NCT04950075 Conventional Chondrosarcoma
Inhibrx Biosciences, Inc
Phase 2
206
Dublin
2021-09-23
Active, closed
A Trial of Pirtobrutinib (LOXO-305) Plus Venetoclax and Rituximab (PVR) Versus Venetoclax and Rituximab (VR) in Previously Treated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL)
NCT04965493 Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma
Loxo Oncology, Inc.
Phase 3
600
Dublin, Waterford
2021-09-20
Active, closed
A Study Evaluating the Efficacy and Safety of Adjuvant Giredestrant Compared With Physician's Choice of Adjuvant Endocrine Monotherapy in Participants With Estrogen Receptor-Positive, HER2-Negative Early Breast Cancer (lidERA Breast Cancer)
NCT04961996 Early Breast Cancer
Hoffmann-La Roche
Phase 3
4,170
Cork, Dublin, Galway, Limerick, Waterford
2021-08-27
Recruiting
A Beta-only IL-2 ImmunoTherapY Study
NCT05086692 Advanced Solid Tumor, Unresectable Solid Tumor, Clear Cell Renal Cell Carcinoma, Triple Negative Breast Cancer
Medicenna Therapeutics, Inc.
Phase 1/2
115
Dublin
2021-08-27
Active, closed
A Study of Bortezomib, Lenalidomide and Dexamethasone (VRd) Followed by Cilta-cel, a CAR-T Therapy Directed Against BCMA Versus VRd Followed by Lenalidomide and Dexamethasone (Rd) Therapy in Participants With Newly Diagnosed Multiple Myeloma for Whom ASCT is Not Planned as Initial Therapy
NCT04923893 Multiple Myeloma
Janssen Research & Development, LLC
Phase 3
743
Dublin
2021-08-19
Active, closed
Ultrasound-facilitated, Catheter-directed, Thrombolysis in Intermediate-high Risk Pulmonary Embolism
NCT04790370 Pulmonary Embolism
Boston Scientific Corporation
Phase 4
544
Dublin, Galway
2021-08-02
Active, closed
A Study to Determine the Efficacy and Safety of Deucravacitinib Compared With Placebo in Participants With Active Psoriatic Arthritis (PsA) Who Are Naïve to Biologic Disease-modifying Anti-rheumatic Drugs
NCT04908202 Psoriatic Arthritis
Bristol-Myers Squibb
Phase 3
670
Manorhamilton, Dublin, Galway
2021-07-13
Active, closed
Long-Term Observational Study on Effectiveness and Safety of Lecigon in Patients With Advanced Parkinson's Disease
NCT05043103 Advanced Parkinson Disease
Britannia Pharmaceuticals Ltd.
Observational
312
Dublin
2021-07-06
Active, closed
Efficacy and Safety Comparison of Niraparib to Placebo in Participants With Human Epidermal Growth Factor 2 Negative (HER2-) Breast Cancer Susceptibility Gene Mutation (BRCAmut) or Triple-Negative Breast Cancer (TNBC) With Molecular Disease
NCT04915755 Neoplasms, Breast
GlaxoSmithKline
Phase 3
40
Dublin
2021-06-28
Active, closed
Phase 3 Study of MRTX849 With Cetuximab vs Chemotherapy in Patients With Advanced Colorectal Cancer With KRAS G12C Mutation (KRYSTAL-10)
NCT04793958 Advanced Colorectal Cancer, Metastatic Colorectal Cancer
Mirati Therapeutics Inc.
Phase 3
461
Dublin
2021-06-24
Active, closed
A Study of T-DXd in Participants With or Without Brain Metastasis Who Have Previously Treated Advanced or Metastatic HER2 Positive Breast Cancer
NCT04739761 Breast Cancer
AstraZeneca
Phase 3
506
Cork, Dublin
2021-06-22
Active, closed
Study of Pembrolizumab (MK-3475) Plus Chemotherapy Versus Placebo Plus Chemotherapy for HR+/HER2- Locally Recurrent Inoperable or Metastatic Breast Cancer (MK-3475-B49/KEYNOTE-B49)
NCT04895358 Breast Neoplasms
Merck Sharp & Dohme LLC
Phase 3
342
Dublin
2021-06-18
Active, closed
FUSION: A Study to Evaluate the Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of ION363 in Amyotrophic Lateral Sclerosis Participants With Fused in Sarcoma Mutations (FUS-ALS)
NCT04768972 Amyotrophic Lateral Sclerosis
Ionis Pharmaceuticals, Inc.
Phase 3
89
Dublin
2021-06-14
Recruiting
Trial-Ready Cohort-Down Syndrome (TRC-DS)
NCT04165109 Down Syndrome, Alzheimer Disease, Dementia
University of Southern California
Observational
550
Dublin
2021-06-07
Active, closed
A Study of Subcutaneous Nivolumab Versus Intravenous Nivolumab in Participants With Previously Treated Clear Cell Renal Cell Carcinoma That is Advanced or Has Spread
NCT04810078 Clear Cell Renal Cell Carcinoma
Bristol-Myers Squibb
Phase 3
681
Tallaght
2021-05-21
Active, closed
Trastuzumab Deruxtecan for Subjects With HER2-Positive Gastric Cancer or Gastro-Esophageal Junction Adenocarcinoma After Progression on or After a Trastuzumab-Containing Regimen (DESTINY-Gastric04)
NCT04704934 Gastric Cancer, Adenocarcinoma, Gastroesophageal Junction Adenocarcinoma
Daiichi Sankyo
Phase 3
490
Cork, Dublin
2021-05-21
Active, closed
Clinical Trial of Inhaled Molgramostim Nebulizer Solution in Autoimmune Pulmonary Alveolar Proteinosis (aPAP)
NCT04544293 Autoimmune Pulmonary Alveolar Proteinosis
Savara Inc.
Phase 3
164
Dublin
2021-05-19
Active, closed
Tafasitamab + Lenalidomide + R-CHOP Versus R-CHOP in Newly Diagnosed High-intermediate and High Risk DLBCL Patients
NCT04824092 Diffuse Large B-cell Lymphoma
Incyte Corporation
Phase 3
899
Dublin, Limerick
2021-05-11
Active, closed
A Study of Atezolizumab Versus Placebo as Adjuvant Therapy in Participants With High-risk Muscle-invasive Bladder Cancer (MIBC) Who Are ctDNA Positive Following Cystectomy
NCT04660344 Muscle-invasive Bladder Cancer
Hoffmann-La Roche
Phase 3
761
Cork, Dublin
2021-05-03
Recruiting
Vitrectomy, Subretinal Tissue Plasminogen Activator (TPA) and Intravitreal Gas for Submacular Haemorrhage Secondary to Exudative (Wet) Age-related Macular Degeneration (TIGER).
NCT04663750 Eye Diseases, Macular Degeneration, Wet, Sub-Macular Hemorrhage
King's College Hospital NHS Trust
Phase 3
210
Waterford
2021-04-16
Active, closed
A Phase 3 Study to Assess Efficacy and Safety of Tafasitamab Plus Lenalidomide and Rituximab Compared to Placebo Plus Lenalidomide and Rituximab in Patients With Relapsed/Refractory (R/R) Follicular Lymphoma or Marginal Zone Lymphoma.
NCT04680052 Follicular Lymphoma, Marginal Zone Lymphoma
Incyte Corporation
Phase 3
654
Dublin, Galway
2021-04-15
Active, closed
A Study of Pembrolizumab (MK-3475) in Combination With Belzutifan (MK-6482) and Lenvatinib (MK-7902), or Pembrolizumab/Quavonlimab (MK-1308A) in Combination With Lenvatinib, Versus Pembrolizumab and Lenvatinib, for Treatment of Advanced Clear Cell Renal Cell Carcinoma (MK-6482-012)
NCT04736706 Carcinoma, Renal Cell
Merck Sharp & Dohme LLC
Phase 3
1,854
Dublin
2021-04-14
Recruiting
Efficacy and Safety of Nemtabrutinib (MK-1026) in Participants With Hematologic Malignancies (MK-1026-003)
NCT04728893 Hematologic Malignancies, Waldenstroms Macroglobulinaemia, Non-Hodgkins Lymphoma, Chronic Lymphocytic Leukaemia
Merck Sharp & Dohme LLC
Phase 2
490
Dublin, Limerick
2021-04-05
Recruiting
FEmale Metabolic Risk and Androgens: an Irish Longitudinal (FEMAIL) Study
NCT04912648 Hyperandrogenism, Metabolic Disease, Sex Hormones Adverse Reaction
Royal College of Surgeons, Ireland
Observational
500
Dublin
2021-04-01
Active, closed
Research Study on Whether Semaglutide Works in People With Non-alcoholic Steatohepatitis (NASH)
NCT04822181 Non-alcoholic Steatohepatitis
Novo Nordisk A/S
Phase 3
1,205
Dublin
2021-04-01
Recruiting
Medication Following Bariatric Surgery for Type 2 Diabetes Mellitus
NCT04432025 Obesity, Type 2 Diabetes
Imperial College London
Not applicable
150
Dublin
2021-04-01
Recruiting
BoStOn SCientific Rhythm MAnagemenT REgiStry
NCT04823663 Cardiac Disease
Boston Scientific Corporation
Observational
12,500
Dublin
2021-03-31
Recruiting
Post-market Surveillance Study of the BD® WavelinQ™ EndoAVF System
NCT04634916 Kidney Disease, End-Stage, End-stage Renal Disease, Arteriovenous Fistula
C. R. Bard
Not applicable
220
2021-03-26
Active, closed
Study of LOXO-305 (Pirtobrutinib) Versus Investigator's Choice (Idelalisib Plus Rituximab or Bendamustine Plus Rituximab) in Patients With Previously Treated Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL)
NCT04666038 Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma
Loxo Oncology, Inc.
Phase 3
238
Dublin
2021-03-09
Active, closed
Ibrutinib Monotherapy Versus Fixed-duration Venetoclax Plus Obinutuzumab Versus Fixed-duration Ibrutinib Plus Venetoclax in Patients With Previously Untreated Chronic Lymphocytic Leukaemia (CLL)
NCT04608318 Chronic Lymphoid Leukemia
German CLL Study Group
Phase 3
897
Cork, Dublin, Galway, Limerick, Waterford
2021-03-01
Recruiting
Axillary Management in Breast Cancer Patients With Needle Biopsy Proven Nodal Metastases After Neoadjuvant Chemotherapy
NCT04109079 Breast Cancer, Sentinel Lymph Node, Neoplasm, Breast
University Hospitals of Derby and Burton NHS Foundation Trust
Not applicable
1,900
Dublin, Galway
2021-02-26
Active, closed
An Efficacy and Safety Study of Luspatercept (ACE-536) Versus Placebo in Subjects With Myeloproliferative Neoplasm-Associated Myelofibrosis on Concomitant JAK2 Inhibitor Therapy and Who Require Red Blood Cell Transfusions
NCT04717414 Myeloproliferative Disorders, Myelofibrosis, Primary Myelofibrosis, Post-Polycythemia Vera Myelofibrosis
Celgene
Phase 3
313
Cork, Dublin
2021-02-25
Active, closed
A Study of Belzutifan (MK-6482) in Combination With Lenvatinib Versus Cabozantinib for Treatment of Renal Cell Carcinoma (MK-6482-011)
NCT04586231 Carcinoma, Renal Cell
Merck Sharp & Dohme LLC
Phase 3
747
Dublin
2021-02-25
Active, closed
Phase 3 Study of MRTX849 (Adagrasib) vs Docetaxel in Patients With Advanced Non-Small Cell Lung Cancer With KRAS G12C Mutation
NCT04685135 Metastatic Non Small Cell Lung Cancer, Advanced Non Small Cell Lung Cancer
Mirati Therapeutics Inc.
Phase 3
453
Tallaght, Dublin, Galway, Limerick
2021-02-23
Active, closed
Long-term Safety and Efficacy of Efanesoctocog Alfa (BIVV001) in Previously Treated Patients With Hemophilia A
NCT04644575 Hemophilia A
Bioverativ, a Sanofi company
Phase 3
261
Dublin
2021-02-23
Recruiting
An Observational Post-marketing Study Using Commercially Approved Biosense Webster (BWI) Medical Devices for the Treatment of Participants With Cardiac Arrhythmias
NCT04750798 Arrhythmias, Cardiac
Biosense Webster, Inc.
Observational
8,000
Dublin
2021-02-22
Recruiting
Statins for Venous Event Reduction in Patients With Venous Thromboembolism
NCT04319627 Venous Thromboembolism, Blood Clot, Post Thrombotic Syndrome
Ottawa Hospital Research Institute
Phase 3
2,700
Dublin
2021-02-10
Recruiting
iCorMicA - Stratified Medicine in Angina
NCT04674449 Microvascular Angina, Angina, Stable, Ischemia With No Obstructive Coronary Arteries (INOCA), Coronary Microvascular Dysfunction (CMD)
NHS Greater Glasgow and Clyde
Not applicable
1,500
Cork, Dublin
2020-12-30
Recruiting
'SOURCE - LUNG' Stereotactic Ablative Radiation Therapy Of UltRaCEntral LUNG Tumours (SOURCE Lung)
NCT04375904 NSCLC/Oligometastatic Cancer (Single Lung Lesion)
Cancer Trials Ireland
Phase 2
68
Dublin
2020-12-22
Active, closed
A Study of Inebilizumab Efficacy and Safety in IgG4- Related Disease
NCT04540497 IgG4 Related Disease
Amgen
Phase 3
135
Cork
2020-12-04
Active, closed
A Study of Trastuzumab Deruxtecan (T-DXd) Versus Trastuzumab Emtansine (T-DM1) in High-risk HER2-positive Participants With Residual Invasive Breast Cancer Following Neoadjuvant Therapy (DESTINY-Breast05)
NCT04622319 HER2-Positive Primary Breast Cancer, Residual Invasive Breast Cancer
Daiichi Sankyo
Phase 3
1,600
Dublin, Cork, Limerick
2020-12-04
Recruiting
Phase 2 Trial of Adagrasib Monotherapy and in Combination With Pembrolizumab and a Phase 3 Trial of Adagrasib in Combination in Patients With a KRAS G12C Mutation KRYSTAL-7
NCT04613596 Advanced Non-Small Cell Lung Cancer, Metastatic Non-Small Cell Lung Cancer
Mirati Therapeutics Inc.
Phase 2/3
626
Cork, Dublin, Galway, Limerick, Waterford
2020-12-02
Recruiting
Chemoradiotherapy Followed by Planned Surgery or by Surveillance and Surgery Only When Needed for Oesophageal Cancer
NCT04460352 Esophageal Squamous Cell Carcinoma
Karolinska University Hospital
Phase 3
1,020
Dublin
2020-11-27
Active, closed
Evaluation of Safety and Performance of the Omega™ LAA (Left Atrial Appendage) Occluder and Omega™ Delivery System in Patients With Non-Valvular Atrial Fibrillation and High Bleeding Risk
NCT04829929 Non-Valvular Atrial Fibrillation
Eclipse Medical Ltd.
Not applicable
200
Dublin
2020-11-17
Recruiting
ErythroPOietin Alfa to Prevent Mortality and Reduce Severe Disability in Critically Ill TRAUMA Patients
NCT04588311 Trauma, Traumatic Injury, Traumatic Brain Injury, Wounds and Injuries
Australian and New Zealand Intensive Care Research Centre
Phase 3
2,500
Beaumont, Cork, Dublin
2020-11-09
Active, closed
Sacituzumab Govitecan in Primary HER2-negative Breast Cancer
NCT04595565 HER2-negative Breast Cancer, Triple Negative Breast Cancer
GBG Forschungs GmbH
Phase 3
1,332
Cork, Dublin, Limerick, Waterford
2020-10-28
Active, closed
A Study Evaluating the Safety, Pharmacokinetics, and Efficacy of Crovalimab Versus Eculizumab in Participants With Paroxysmal Nocturnal Hemoglobinuria (PNH) Currently Treated With Complement Inhibitors
NCT04432584 Paroxysmal Nocturnal Hemoglobinuria
Hoffmann-La Roche
Phase 3
190
Dublin
2020-09-30
Active, closed
Multivessel TALENT
NCT04390672 Coronary Artery Disease, Myocardial Ischemia, Coronary Disease, Heart Diseases
National University of Ireland, Galway, Ireland
Not applicable
1,550
Galway
2020-09-22
Recruiting
FaR-RMS: An Overarching Study for Children and Adults With Frontline and Relapsed RhabdoMyoSarcoma
NCT04625907 Rhabdomyosarcoma
University of Birmingham
Phase 1/2
1,672
Crumlin
2020-09-17
Active, closed
Using FDG-PET/CT to Assess Response of Bone-Dominant Metastatic Breast Cancer, FEATURE Study
NCT04316117 Anatomic Stage IV Breast Cancer AJCC v8, Hormone Receptor Positive Breast Carcinoma, Metastatic Breast Carcinoma, Prognostic Stage IV Breast Cancer AJCC v8
ECOG-ACRIN Cancer Research Group
Phase 2
138
Cork
2020-09-15
Active, closed
A Study of Belzutifan (MK-6482) in Participants With Advanced Renal Cell Carcinoma (MK-6482-013)
NCT04489771 Carcinoma, Renal Cell
Merck Sharp & Dohme LLC
Phase 2
154
Cork, Dublin
2020-09-13
Active, closed
Real World Clinical Outcomes With Novel Modulator Therapy Combinations in People With CF (RECOVER)
NCT04602468 Cystic Fibrosis, Cystic Fibrosis Liver Disease, Cystic Fibrosis in Children, Adherence, Medication
Royal College of Surgeons, Ireland
Phase 4
206
Dublin, Limerick, Tallaght
2020-09-03
Recruiting
BOLD-100 in Combination With FOLFOX for the Treatment of Advanced Solid Tumours
NCT04421820 Colorectal Cancer, Pancreatic Cancer, Gastric Cancers, Cholangiocarcinoma
Bold Therapeutics, Inc.
Phase 1/2
220
Dublin
2020-08-28
Active, closed
STABILITY 2: Anterior Cruciate Ligament Reconstruction +/- Lateral Tenodesis With Patellar vs Quad Tendon
NCT03935750 Anterior Cruciate Ligament Injury, Anterior Cruciate Ligament Reconstruction, Joint Instability
University of Pittsburgh
Not applicable
1,272
Dublin
2020-07-28
Recruiting
A Treatment Study Protocol for Participants 0-45 Years With Acute Lymphoblastic Leukaemia
NCT04307576 Leukemia, Acute Lymphoblastic
Mats Heyman
Phase 3
6,430
Dublin
2020-07-13
Active, closed
A Study to Compare Safety and Efficacy of High Doses of Eteplirsen in Participants With Duchenne Muscular Dystrophy (DMD) (MIS51ON)
NCT03992430 Muscular Dystrophy, Duchenne
Sarepta Therapeutics, Inc.
Phase 3
160
Dublin
2020-07-13
Active, closed
Isatuximab in Combination With Lenalidomide and Dexamethasone in High-risk Smoldering Multiple Myeloma
NCT04270409 Plasma Cell Myeloma
Sanofi
Phase 3
337
Dublin
2020-06-16
Recruiting
Study to Learn More About the Safety and Effectiveness of the Drug VITRAKVI During Routine Use in Patients With TRK Fusion Cancer Which is Locally Advanced or Spread From the Place Where it Started to Other Places in the Body
NCT04142437 Locally Advanced or Metastatic Solid Tumor Harboring an NTRK Gene Fusion
Bayer
Observational
150
Multiple Locations
2020-04-03
Active, closed
Darolutamide Augments Standard Therapy for Localised Very High-Risk Cancer of the Prostate
NCT04136353 Prostate Cancer
University of Sydney
Phase 3
1,100
Rathgar, Cork, Dublin, Galway
2020-03-31
Recruiting
TUBectomy With Delayed Oophorectomy in High Risk Women to Assess the Safety of Prevention
NCT04294927 BRCA1 Gene Mutation, BRCA2 Gene Mutation, RAD51C Gene Mutation, RAD51D Gene Mutation
University Medical Center Nijmegen
Not applicable
3,000
Cork
2020-03-01
Active, closed
Safety and Efficacy of IMC-F106C as a Single Agent and in Combination With Checkpoint Inhibitors
NCT04262466 Select Advanced Solid Tumors
Immunocore Ltd
Phase 1/2
410
Dublin
2020-02-25
Active, closed
A Study of Selexipag as Add-On Treatment to Standard of Care in Children With Pulmonary Arterial Hypertension
NCT04175600 Hypertension, Pulmonary
Actelion
Phase 3
138
Dublin
2020-01-16
Active, closed
Paediatric Sjögren Syndrome Cohort Study and Repository (PaedSSCoRe)
NCT04762108 Sjogren's Syndrome Childhood-onset
University College, London
Observational
300
Dublin
2020-01-11
Active, closed
PROACTIVE-HF IDE Trial Heart Failure NYHA Class III
NCT04089059 Heart Failure NYHA Class III
Endotronix, Inc.
Not applicable
738
Galway
2020-01-10
Active, closed
Primary Cytoreductive Surgery With or Without Hyperthermic Intraperitoneal Chemotherapy (HIPEC)
NCT03772028 Ovarian Cancer
The Netherlands Cancer Institute
Phase 3
538
Dublin
2020-01-01
Active, closed
A Study of Gilteritinib Versus Midostaurin in Combination With Induction and Consolidation Therapy Followed by One-year Maintenance in Patients With Newly Diagnosed Acute Myeloid Leukemia or Myelodysplastic Syndromes With Excess Blasts-2 With FLT3 Mutations Eligible for Intensive Chemotherapy
NCT04027309 Acute Myeloid Leukemia, Myelodysplastic Syndrome With Excess Blasts-2
Stichting Hemato-Oncologie voor Volwassenen Nederland
Phase 3
777
Cork, Dublin, Galway, Limerick
2019-12-20
Recruiting
Melanoma Margins Trial-II: 1cm v 2cm Wide Surgical Excision Margins for AJCC Stage II Primary Cutaneous Melanoma
NCT03860883 Cutaneous Melanoma, Stage II
Melanoma and Skin Cancer Trials Limited
Not applicable
2,998
Cork, Dublin
2019-12-17
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Priya Life Science (2026). Clinical trial register: studies with an Irish investigative site. Derived from ClinicalTrials.gov, U.S. National Library of Medicine. Retrieved 23 September 2026. https://priyalifescience.com/clinical-trials-ireland?page=5

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