Glycolytic Phenotype (vLapeak) and Magnitude of Skeletal Muscle Hypertrophy After Resistance Training

Condition(s) studied

Investigational drug(s) / intervention(s)

Hypertrophy-focused Resistance Training: Standardized training consisting of twice-weekly supervised sessions for 8 weeks. Each session includes 4 sets of 8-12 repetitions of leg press (or Smith-machine squat) and leg extensions. Training intensity progresses from an RPE of 6 to voluntary muscular failure starting from week three.

Study summary

The HyperLa study investigates whether a person's "glycolyticness"-the efficiency with which their body uses glycolysis for energy-can predict how much their muscles will grow (hypertrophy) in response to resistance training. Participants will undergo a specialized "vLapeak" test, which measures the maximal rate of lactate accumulation during a 10-second all-out cycling sprint, to determine their individual glycolytic power. Following this initial assessment, participants will complete eight weeks of standardized, twice-weekly resistance training focused on the lower body. The study aims to determine if individuals with higher initial vLapeak values experience greater increases in muscle size compared to those with lower values. This research may help explain why people respond differently to exercise and support the development of personalized training programs.

Eligibility

Primary outcome measure(s)

• Change in mid-thigh Muscle Thickness — Baseline and Week 8 (completion of training intervention)
  Change in mid-thigh muscle thickness (combination of rectus femoris and vastus intermedius) as measured by ultrasound.
• Change in lateral-thigh Muscle Thickness — Baseline and Week 8 (completion of training intervention)
  Change in lateral thigh muscle thickness (combination of vastus lateralis and vastus intermedius) as measured by ultrasound.

Trial sites (8)

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