Exercise Timing and Postprandial Glucose Responses

Condition(s) studied

Investigational drug(s) / intervention(s)

Timed Endurance Exercise: The exercise intervention consists of a 45 minute continuous outdoor run performed on a standardized route. Participants are instructed to maintain a consistent running pace across all exercise conditions. Exercise intensity is standardized using a target heart rate corresponding to 75 to 85 percent of maximal heart rate, and participants must be able to complete 45 minutes of continuous running at this intensity without stopping. Heart rate, duration, distance, and pace are recorded using a heart rate monitor and GPS enabled device. Ambient temperature and precipitation are recorded for each session. Exercise sessions may be rescheduled in cases of extreme weather or acute illness.

No Exercise Control: This intervention involves a non-exercise control condition

Study summary

This interventional crossover study examines the effect of exercise timing relative to meal intake on postprandial glucose responses in healthy, physically active young adults. Participants complete five experimental conditions involving endurance exercise performed before or after breakfast or dinner, as well as a non-exercise control condition, while wearing a continuous glucose monitoring device.

Postprandial glucose responses are assessed for the three consecutive meals following each exercise session. Following morning exercise, outcomes are assessed after breakfast, lunch, and dinner on the same day. Following evening exercise, outcomes are assessed after dinner on the same day and after breakfast and lunch on the subsequent day. All meals are standardized and consumed at fixed clock times.

Eligibility

Primary outcome measure(s)

• 3-hour postprandial glucose area under the curve (AUC) — During each intervention condition within the 14-day study period, assessed over the 3-hour period following each of the three consecutive meals after each condition
  The area under the curve for interstitial glucose concentration during the 3-hour period following each of the three consecutive meals assessed after each exercise or control condition, measured using continuous glucose monitoring.

Trial sites (1)

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