Preoperative Physical Exercise, Nutritional Support, and Psychological Intervention (Multimodal Prehabilitation) to Strengthen Patients' Overall Health and Reduce Postoperative Complications
Multimodal Prehabilitation: Multimodal prehabilitation includes preoperative exercise (HIIT), nutritional optimization and psychological support
Study summary
In this prospective, randomized, controlled trial patients undergoing major gastrointestinal cancer surgery will be exercised (intervention group) 4 weeks before surgery with a high-intensity interval training (HIIT). They will also receive a specialized nutrition therapy and psychological support (multimodal prehabilitation). Aim of this study is to find out if the prehabilitation group is more resilient to postoperative complications when compared to the control group that will receive standard of care. Another goal is to unravel the underlying mechanisms that are stimulated by exercise like enhancing vascular function, improving immune system response, strengthen cellular tumor defense and optimizing neurological outcome.
Eligibility
Sex
ALL
Min age
18 Years
Max age
80 Years
Healthy volunteers
No
Inclusion Criteria:
* Candidate to elective major gastrointestinal cancer surgery (pelvic exenteration, cytoreductive surgery, oesophagectomy, transhiatal gastrectomy, hepatectomy, pancreatectomy, rectum resection)
* High risk for surgical complications defined by presence of comorbid disease such as deconditioning, heart disease, diabetes, renal impairment or morbid obesity
* Duke Activity Status Index score (DASI) \<402
* Schedule allowing for at least 4 weeks for intervention with multimodal prehabilitation prior to surgery / willingness to exercise
Exclusion Criteria:
* Non-elective surgery
* Unstable cardiac or respiratory disease
* Locomotor limitations precluding exercise training
* Cognitive deterioration impeding adherence to the programme
* Enrolment in other research studies affecting study endpoint
Primary outcome measure(s)
Postoperative complications defined as Clavien-Dindo Classification grade III-V — During hospital stay until the day of discharge (assessed up to five days)
Trial sites (1)
Facility
City
Region
Status
University Hospital of Cologne
Cologne
Germany
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This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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