Functional MRI for Monitoring Progression and Assessing Trends in ILD

Condition(s) studied

Investigational drug(s) / intervention(s)

Lung MRI Protocol with Functional and Contrast-Enhanced Sequences: Participants will undergo a lung MRI protocol consisting of structural imaging, non-contrast functional imaging, and contrast-enhanced imaging. Some sequences are custom-developed and performed during free breathing to accommodate patients with respiratory limitations.

Study summary

The main objective of this study is to investigate the utility of functional MRI to differentiate, characterize, and monitor subgroups of ILD. This can be broken down into three specific objectives:

Determine if ILD features observed on high-resolution computed tomography (HRCT), such as ground glass opacities (GGO), are functionally different.

Analyse MRI metrics within each subgroup to determine whether these metrics distinguish different ILDs.

Assess MRI metrics longitudinally to see if these parameters change with disease progression, stability, or reversibility.

Eligibility

Primary outcome measure(s)

• Identification of ILD Subtypes Using Baseline MRI Metrics — Baseline (first MRI scan)
  Assess whether baseline MRI metrics can accurately differentiate subtypes of interstitial lung disease, using clinician diagnosis (based on multidisciplinary discussion) as the reference standard.

Trial sites (2)

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