Investigation of a New Window Into Intracranial Pressure: Venous Occlusion Pressure of the Isolated Periorbital Vein

Condition(s) studied

Investigational drug(s) / intervention(s)

venous occlusion pressure Measurement: non-invasive venous occlusion pressure of a targeted periorbital vein is measured in parallel to clinical standard CSF dyanmic testing including standard CSF infusiontest

Study summary

Elevated intracranial pressure (ICP) occurs when pressure inside the skull rises above normal levels, potentially leading to brain damage or herniation. Monitoring ICP is critical for managing conditions like brain tumors, traumatic brain injury, and stroke. Current ICP monitoring methods are invasive and carry risks, including infection and brain damage. For less severe cases, lumbar puncture is a safer, less invasive alternative. This study explores the potential of a non-invasive method, using venous pressure near the eye, to estimate ICP. The goal is to assess whether the results from this non-invasive approach are similar to the invasive lumbar CSF pressure measurements.

Eligibility

Primary outcome measure(s)

• Venous occlusion pressure measurement (mmHg) — 60 minutes
  Mean venous occlusion pressure of one isolated target periorbital frontal vein of 6 consecutive measurements in mmHg (mask inflated) during routine infusion test in recumbent lateral position
• intracranial Pressure (ICP) in mmHg — 60 minutes
  Invasive lumbar intracranial pressure measurements in mmHg (mean over a 1-minute window aligned with start of venous occlusion measurements, in mmHg) during routine infusion test in recumbent lateral position

Trial sites (1)

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