HIV Resistance, Molecular Epidemiology and New Treatment Strategies in the Eastern European Region and in Russia

Inclusion Criteria: * naïve patients starting 2nd generation INSTI treatment * first line patients under 2nd generation INSTI treatment with either viral RNA sequence before therapy start, or PBMC available with PBMC sample date not more than 3 years from therapy start date (with reasonably sure history of no failure in the interval from therapy start date to PBMC sample date\]). Exclusion Criteria: * patients not having a signed informed consent for the EIDB data repository, if required by local/national legislation in order to have data in the common data repository. * patients not having Signed Informed consent for the present study, if required by local authorities iii) Persons aged \< 18 at baseline