Women and men show marked differences in cardiovascular risk profile and outcome. Women experience fewer cardiovascular events than men before menopause, but this relationship seems to reverse at menopause. These disparities are probably due to hormonal factors, especially the female sex hormone estrogen seems to have a protective influence on the development of atherosclerotic plaques premenopausal.
The underlying mechanisms of the effect of estrogens on the vessel wall are still insufficiently investigated. In this study, menopause related effects on leukocyte distribution and function as well on platelets and their aggregational response will be evaluated.
Eligibility
Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
Accepted
Inclusion Criteria:
* Age \> 18 years
* Male, female, diverse patients with current treatment in the Department of Cardiology, Pneumology and Angiology.
* Persons who are able to understand and follow the instructions of the study staff
* Written informed consent
Exclusion Criteria:
* Age \< 18 years
* Lack of written consent to participate in the study
* coagulation disorders
Primary outcome measure(s)
Leukocyte distribution measured by flow cytometry — single time, up to one day after inclusion CD45 (Leukocytes), CD3 (T-cells), CD14 (Monocytes), CD16 (Granulocytes), CD19 (B-cells)
Platelet function — single time, up to one day after inclusion measured by light transmittance aggregometry (Parameters: Maximum of Aggregation, Slope
Platelet surface markers, platelet leukocyte crosstalk (CD40, CD40L) — single time, up to one day after inclusion measured by flow cytometry (FACS)
Trial sites (1)
Facility
City
Region
Status
University-Hospital Düsseldorf Division of Cardiology, Pulmonary Disease and Vascular Medicine
Düsseldorf
Germany
Recruiting
More Heinrich-Heine University, Duesseldorf trials in Germany
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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