Next-Generation-Sequencing Approach to Neutropenic Sepsis

Inclusion Criteria: * Age ≥18 years * Informed consent * Neutropenia defined as \<500 ANC (Absolute neutrophil Count)/µl or \<1000 WBC (White bloddcell Count)/µl if ANC is not available * Fever (with an onset \< 24h) or Sepsis (with an onset \<24h) Patients with a life-threatening - organ dysfunction caused by a dysregulated host response to a suspected or proven infection. Exclusion Criteria: * Age \< 18 years * Refusal or inability to give consent Inability to give informed consent if no acceptable patient representative is available * Patients who had previously been included, but develop a new episode of fever during the same hospitalization, will not be included a second time * Death is deemed imminent and inevitable