A Study to Evaluate Dostarlimab Plus Carboplatin-paclitaxel Versus Placebo Plus Carboplatin-paclitaxel in Participants With Recurrent or Primary Advanced Endometrial Cancer
Dostarlimab: Participants will be administered dostarlimab
Placebo matching dostarlimab: Participants will be administered placebo matching dostarlimab
Carboplatin: Participants will be administered carboplatin
Paclitaxel: Participants will be administered paclitaxel
Niraparib: Participants will be administered niraparib
Placebo matching Niraparib: Participants will be administered placebo matching Niraparib
Study summary
This is a 2 part study. Part 1 is to evaluate the efficacy and safety of dostarlimab plus carboplatin-paclitaxel followed by dostarlimab versus placebo plus carboplatin-paclitaxel followed by placebo; and Part 2 is to evaluate the efficacy and safety of dostarlimab plus carboplatin-paclitaxel followed by dostarlimab plus niraparib versus placebo plus carboplatin-paclitaxel followed by placebo in participants with recurrent or primary advanced (Stage III or IV) endometrial cancer.
Eligibility
Sex
FEMALE
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria:
Part 1 and Part 2:
* Female participant is at least 18 years of age.
* Participant has histologically or cytologically proven endometrial cancer with recurrent or advanced disease.
* Participant must have primary Stage III or Stage IV disease or first recurrent endometrial cancer with a low potential for cure by radiation therapy or surgery alone or in combination and meet at least one of the following criteria;
1. Participant has primary Stage IIIA to IIIC1 disease with presence of evaluable or measurable disease per Response Evaluation Criteria in Solid Tumors (RECIST) version (v).1.1 based on Investigator's assessment. Lesions that are equivocal or can be representative of post-operative change should be biopsied and confirmed for the presence of tumor;
2. Participant has primary Stage IIIC1 disease with carcinosarcoma, clear cell, serous, or mixed histology (containing greater than or equal to \[\>=\] 10 percent carcinosarcoma, clear cell, or serous histology) regardless of presence of evaluable or measurable disease on imaging;
3. Participant has primary Stage IIIC2 or Stage IV disease regardless of the presence of evaluable or measurable disease;
4. Participant has first recurrent disease and is naïve to systemic anticancer therapy;
5. Participant has received prior neo-adjuvant/adjuvant systemic anticancer therapy and had a recurrence or progression of disease (PD) \>=6 months after completing treatment (first recurrence only).
* Participant has an ECOG performance status of 0 or 1.
* Participant has adequate organ function.
Part 2 only:
* Participants must have normal blood pressure (BP) or adequately treated and controlled hypertension (systolic BP lesser than or equal to \[\<=\] 140 millimeter of mercury \[mmHg\] and diastolic BP \<=90 mmHg).
* Participants must be able to take medication orally, by mouth (PO).
Exclusion Criteria:
Part 1 and Part 2:
* Participant has received neo-adjuvant/adjuvant systemic anticancer therapy for primary Stage III or IV disease and:
1. has not had a recurrence or PD prior to first dose on the study OR
2. has had a recurrence or PD within 6 months of completing systemic anticancer therapy treatment prior to first dose on the study.
* Participant has had \>1 recurrence of endometrial cancer.
* Participant has received prior therapy with an anti-programmed cell death protein 1 (anti-PD-1), anti-PD-ligand 1 (anti-PD-L1), or anti-PD-ligand 2 (anti-PD-L2) agent.
* Participant has received prior anticancer therapy (chemotherapy, targeted therapies, hormonal therapy, radiotherapy, or immunotherapy) within 21 days or \<5 times the half-life of the most recent therapy prior to Study Day 1, whichever is shorter.
* Participant has a concomitant malignancy, or participant has a prior non-endometrial invasive malignancy who has been disease-free for \<3 years or who received any active treatment in the last 3 years for that malignancy. Non-melanoma skin cancer is allowed.
* Participant has known uncontrolled central nervous system metastases, carcinomatosis meningitis, or both.
* Participant has not recovered (that is \[i.e.\], to Grade \<=1 or to Baseline) from cytotoxic therapy induced AEs or has received transfusion of blood products (including platelets or red blood cells) or administration of colony-stimulating factors (including granulocyte colony-stimulating factor \[G-CSF\], granulocyte macrophage colony-stimulating factor \[GM-CSF\], or recombinant erythropoietin) within 21 days prior to the first dose of study drug.
* Participant has not recovered adequately from AEs or complications from any major surgery prior to starting therapy.
* Participant is currently participating and receiving study treatment or has participated in a study of an investigational agent and received study treatment or used an investigational device within 4 weeks of the first dose of treatment.
* Participant is considered a poor medical risk due to a serious, uncontrolled medical disorder, nonmalignant systemic disease, or active infection requiring systemic therapy.
* Participant has received, or is scheduled to receive, a live vaccine within 30 days before first dose of study treatment, during study treatment, and for up to 180 days after receiving the last dose of study treatment.
Part 2 only:
* Participant has received prior therapy with a poly (adenosine diphosphate \[ADP\]-ribose) polymerase (PARP) inhibitor.
* Participant has clinically significant cardiovascular disease.
* Participant has any known history or current diagnosis of myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML).
* Participant is at increased bleeding risk due to concurrent conditions.
* Participant has participated in Part 1 of this study
Primary outcome measure(s)
Parts 1 and 2: Progression-Free Survival (PFS) - investigator assessment — Up to 6 years
Part 1: Overall survival — Up to 6 years
Trial sites (169)
Facility
City
Region
Status
GSK Investigational Site
Phoenix
Arizona
GSK Investigational Site
Scottsdale
Arizona
GSK Investigational Site
Tucson
Arizona
GSK Investigational Site
Tucson
Arizona
GSK Investigational Site
Newport Beach
California
GSK Investigational Site
Palo Alto
California
GSK Investigational Site
Deerfield Beach
Florida
GSK Investigational Site
Jacksonville
Florida
GSK Investigational Site
Miami
Florida
GSK Investigational Site
Miami
Florida
GSK Investigational Site
Orlando
Florida
GSK Investigational Site
Atlanta
Georgia
GSK Investigational Site
Augusta
Georgia
GSK Investigational Site
Savannah
Georgia
GSK Investigational Site
Hinsdale
Illinois
GSK Investigational Site
Zion
Illinois
GSK Investigational Site
Fort Wayne
Indiana
GSK Investigational Site
Indianapolis
Indiana
GSK Investigational Site
Indianapolis
Indiana
GSK Investigational Site
Iowa City
Iowa
GSK Investigational Site
Lexington
Kentucky
GSK Investigational Site
Covington
Louisiana
GSK Investigational Site
New Orleans
Louisiana
GSK Investigational Site
Shreveport
Louisiana
GSK Investigational Site
Boston
Massachusetts
GSK Investigational Site
Springfield
Massachusetts
GSK Investigational Site
Detroit
Michigan
GSK Investigational Site
St Louis
Missouri
GSK Investigational Site
Lebanon
New Hampshire
GSK Investigational Site
Albuquerque
New Mexico
GSK Investigational Site
Rio Rancho
New Mexico
GSK Investigational Site
Albany
New York
GSK Investigational Site
Mineola
New York
GSK Investigational Site
New York
New York
GSK Investigational Site
The Bronx
New York
GSK Investigational Site
Charlotte
North Carolina
GSK Investigational Site
Durham
North Carolina
GSK Investigational Site
Kernersville
North Carolina
GSK Investigational Site
Mount Airy
North Carolina
GSK Investigational Site
Winston-Salem
North Carolina
+ 129 more sites — see the full list on the official registry below.
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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